Evidence map›Paper›PMID 31068388›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing β-Selection.

Tomas Zikmund, Juraj Kokavec, Tereza Turkova, Filipp Savvulidi, Helena Paszekova, Sona Vodenkova, Radislav Sedlacek, Arthur I Skoultchi, Tomas Stopka

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Tomas ZikmundBIOCEV, First Faculty of Medicine, Charles University, Vestec 25250, Czech Republic.ORCID 0000-0003-2452-3749
Juraj KokavecBIOCEV, First Faculty of Medicine, Charles University, Vestec 25250, Czech Republic.ORCID 0000-0003-0267-4570
Tereza TurkovaBIOCEV, First Faculty of Medicine, Charles University, Vestec 25250, Czech Republic.ORCID 0000-0002-5329-1812
Filipp SavvulidiInstitute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague 12853, Czech Republic.
Helena PaszekovaBIOCEV, First Faculty of Medicine, Charles University, Vestec 25250, Czech Republic.ORCID 0000-0002-6479-6592
Sona VodenkovaInstitute of Experimental Medicine, Czech Academy of Sciences, Prague 14220, Czech Republic.ORCID 0000-0003-0315-5668
Radislav SedlacekCzech Centre for Phenogenomics, Institute of Molecular Genetics, Czech Academy of Sciences, Vestec 25250, Czech Republic; and.
Arthur I SkoultchiDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx 10461, NY.
Tomas StopkaBIOCEV, First Faculty of Medicine, Charles University, Vestec 25250, Czech Republic; tstopka@lf1.cuni.cz.ORCID 0000-0001-7236-6894
Charles University · CZAlbert Einstein College of Medicine · USCzech Academy of Sciences, Institute of Molecular Genetics · CZ

Funding

IN VIVO ANALYSIS OF MOUSE H1 HISTONE FUNCTIONR01CA079057 · NCI · YESHIVA UNIVERSITY · PI SKOULTCHI, ARTHUR I · 1998 to 2013
$5.4M
Functions of Mammalian H1 Linker Histones in Gene Regulation and DevelopmentR01GM116143 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SKOULTCHI, ARTHUR I · 2015 to 2018
$1.9M
Control of the Erythroid Terminal Differentiation DecisionR01DK096266 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SKOULTCHI, ARTHUR I · 2012 to 2016
$1.8M
NCI NIH HHS R01 CA079057NIDDK NIH HHS R01 DK096266NIGMS NIH HHS R01 GM116143
6 · The paper itself

Abstract

Development of lymphoid progenitors requires a coordinated regulation of gene expression, DNA replication, and gene rearrangement. Chromatin-remodeling activities directed by SWI/SNF2 superfamily complexes play important roles in these processes. In this study, we used a conditional knockout mouse model to investigate the role of Smarca5, a member of the ISWI subfamily of such complexes, in early lymphocyte development.

Indexed as

Adenosine TriphosphatasesAnimalsB-LymphocytesCell DifferentiationCells, CulturedChromosomal Proteins, Non-HistoneClonal Selection, Antigen-MediatedGene RearrangementLymphoid Progenitor CellsMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, B-CellReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaThymocytesAdenosine TriphosphatasesChromosomal Proteins, Non-HistoneReceptors, Antigen, B-CellReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSmarca5 protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53

Identifiers

PMID31068388
PMCPMC6548592
OpenAlexW2944649131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.