Evidence map›Paper›PMID 31068301›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2019

[Dexmedetomidine alleviates cognitive dysfunction induced by tibial fracture in rats].

Jinwei Zhang, Xiaobao Zhang, Haitao Qian, Jizheng Cui, Xiaoping Gu

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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jinwei ZhangDepartment of Anesthesiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China.
Xiaobao ZhangDepartment of Anesthesiology, Lianyungang Clinical Medical College of Nanjing Medical University, Lianyungang 222000, China.
Haitao QianDepartment of Anesthesiology, Lianyungang Clinical Medical College of Nanjing Medical University, Lianyungang 222000, China.
Jizheng CuiDepartment of Anesthesiology, Lianyungang Clinical Medical College of Nanjing Medical University, Lianyungang 222000, China.
Xiaoping GuDepartment of Anesthesiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China.
Nanjing Drum Tower Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the effect of dexmedetomidine (Dex) on cognitive dysfunction induced by tibial fracture in rats.

methodsSixteen male SD rats were randomized into control group and tibial fracture group, and the behavior indicators were measured on days 1, 3, 5 and 7 after tibial fracture and the expressions of CX3L1 protein and mRNA in the hippocampus were detected. Another 24 male SD rats were randomly divided into control group, tibial fracture group, and tibia fracture with CX3CL1 antibody group, and the behavior indicators and hippocampal CX3L1 protein expression were evaluated after corresponding treatments. In another experiment, we randomized 24 male SD rats into control group, tibial fracture group and tibial fracture with Dex treatment, and tested their hippocampal CX3L1 protein and mRNA expressions as well as the behavior indicators after the treatments.

resultsCompared with the control rats, the rats with tibial fracture spent significantly less time in the novel arm on days 1, 3, 5 and 7 after the fracture (

conclusionsDex can alleviate cognitive dysfunction induced by tibial fracture in rats by increasing the expression of CX3CL1 in the hippocampus.

Indexed as

Cognitive DysfunctionTibial FracturesAnimalsDexmedetomidineHippocampusMaleRatsRats, Sprague-DawleyDexmedetomidinecognitive dysfunctionsCX3CL1dexmedetomidinetibial fracture

Identifiers

PMID31068301
PMCPMC6765688
OpenAlexW2984878407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.