Evidence map›Paper›PMID 31068300›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2019

[Silencing RRM1 gene reverses paclitaxel resistance in human breast cancer cell line MCF- 7/R by inducing cell apoptosis].

Nannan Tian, Lei Zhou, Danni Yang, Huanxian Wu, Yunci Ma, Lin Lü, Shaoyu Wu

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In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nannan TianSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Lei ZhouSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Danni YangSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Huanxian WuSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Yunci MaSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Lin LüSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Shaoyu WuSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects of ribonucleotide reductase catalytic subunit M1 (RRM1) gene silencing on drug resistance of human breast cancer cell line MCF-7/R.

methodsWe established a paclitaxel-resistant breast cancer MCF-7 cell line (MCF-7/R) by exposing the cells to high-concentration paclitaxel in a short time. Small interfering RNAs (siRNAs) targeting RRM1 were designed to silence RRM1 expression in human breast cancer MCF-7/R cells. MTT assay was used to detect the IC

resultsWe detected significantly higher expressions of RRM1 at both the mRNA and protein levels in the drug-resistant MCF- 7/R cells than in the parental MCF-7 cells (

conclusionsRRM1 gene silencing can reverse paclitaxel resistance in human breast cancer cell line MCF-7/R by promoting cell apoptosis.

Indexed as

Breast NeoplasmsAnimalsApoptosisDrug Resistance, NeoplasmGene SilencingHumansMCF-7 CellsMiceMice, NudePaclitaxelRibonucleoside Diphosphate ReductaseRibonucleotide ReductasesRNA, Small InterferingTumor Suppressor ProteinsPaclitaxelRibonucleoside Diphosphate ReductaseRibonucleotide ReductasesRNA, Small InterferingRRM1 protein, humanRrm1 protein, mouseTumor Suppressor Proteinsbreast cancerdrug resistanceMCF-7paclitaxelribonucleotide reductase catalytic subunit M1small interfering RNA

Identifiers

PMID31068300
PMCPMC6765681
OpenAlexW2945907688

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.