ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2019
[Expression of connexin 43 in peripheral blood monocytes from patients with acute coronary syndrome].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 0 citations in OpenAlex.
- [Correlation of serum ferredoxin 1 and lipoic acid levels with severity of coronary artery disease].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
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5 authors at 1 institution in 1 country.
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Abstract
objectiveTo investigate the expression of connexin 43 (Cx43) in peripheral blood monocytes (PBMCs) from patients with acute coronary syndrome (ACS) and its clinical implications.
methodsWe prospectively collected the clinical data from 40 patients with ACS including 20 with unstable angina pectoris (UAP) and 20 with acute myocardial infarction (AMI) admitted in our department between January, 2018 and June, 2018, with 20 healthy subjects undergoing routine physical examinations serving as the control group. Peripheral blood samples were obtained from all the participants and plasma and PBMCs were separated. Enzyme-linked immunosorbent assay (ELISA) and turbidimetric inhibition immunoassay (TIIA) were used for analysis of plasma levels of interleukin (IL)-1β and high sensitive C-reactive protein (hs-CRP), respectively; real-time quantitative RT-PCR and Western blotting were used to detect the mRNA and protein levels of Cx43 in the PBMCs.
resultsCompared with the control group, the patients with UAP showed significantly increased plasma levels of IL-1β and hs-CRP (
conclusionsPatients with UAP and AMI have activated inflammatory responses and reverse changes in Cx43 expression in the PBMCs, suggesting the different roles of Cx43 in the pathogenic mechanisms of different types of ACS.
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