Evidence map›Paper›PMID 31068241›Full record

ArticleBJPsych open2019

Predicting major mental illness: ethical and practical considerations.

Stephen M Lawrie, Sue Fletcher-Watson, Heather C Whalley, Andrew M McIntosh

Abstract read
In one paragraph

Article in BJPsych open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. BJPsych open · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Capturing mood dynamics through adolescent smartphone social communication.Journal of psychopathology and clinical science · 2023
    Article
  12. A Call to Action on Assessing and Mitigating Bias in Artificial Intelligence Applications for Mental Health.Perspectives on psychological science : a journal of the Association for Psychological Science · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stephen M LawrieHead of Psychiatry, Division of Psychiatry and Patrick Wild Centre,University of Edinburgh,Scotland, UK.ORCID https://orcid.org/0000-0002-2444-5675
Sue Fletcher-WatsonSenior Lecturer, Division of Psychiatry and Patrick Wild Centre,University of Edinburgh,Scotland, UK.
Heather C WhalleySenior Research Fellow, Division of Psychiatry,University of Edinburgh,Scotland, UK.
Andrew M McIntoshProfessor of Biological Psychiatry, Division of Psychiatry and Centre for Cognitive Ageing and Cognitive Epidemiology,University of Edinburgh,Scotland, UK.

Funding

Medical Research Council MC_PC_17209
6 · The paper itself

Abstract

SummaryAn increasing body of genetic and imaging research shows that it is becoming possible to forecast the onset of major psychiatric disorders such as depression and schizophrenia before people become ill with ever improving accuracy. Practical issues such as the optimal combination of clinical and biological variables are being addressed, but the application of predictive algorithms to individuals or in routine clinical settings have yet to be tested. The development of predictive methods in mental health comes with substantial ethical questions, including whether people wish to know their level of risk, as well as individual and societal attitudes to the potential adverse effects of data sharing, early diagnosis and treatment, which so far have been largely ignored. Preliminary data suggests that at least some people think predictive research is valuable and would take part in such studies, and some would welcome knowing the results. Future initiatives should systematically assess opinions and attitudes in conjunction with scientific and technical advances.Declaration of interestIn the past 3 years, S.M.L. has received personal fees from Otsuaka, Sunovion and Janssen, and research grant support from Janssen and Lundbeck. A.M.M. has received research support from the Sackler Trust, Eli Lilly and Janssen. S.M.L. is part of the PSYSCAN consortium.

Indexed as

Bipolar affective disordersdepressive disordersethicsimagingpsychotic disorders

Identifiers

PMID31068241
PMCPMC6469234

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.