ArticleParasites & vectors2019
Activity of the prophenoloxidase system and survival of triatomines infected with different Trypanosoma cruzi strains under different temperatures: understanding Chagas disease in the face of climate change.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Expression of Proteins, Glycoproteins, and Transcripts in the Guts of Fasting, Fed, andPathogens (Basel, Switzerland) · 2023Pooled it
- The impact of climate change on neglected tropical diseases: a systematic review.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2021Pooled it
- The Transcriptomic Response Along an Urbanization Gradient Is Also Temperature-Dependent in a Freshwater Insect.Molecular ecology · 2026Article
- Acute sublethal heat stress impairs blood feeding and trypanosome infection in the kissing bug, Rhodnius prolixus.Journal of medical entomology · 2026Article
- Temperature variability increases Trypanosoma cruzi load but not the extrinsic incubation period in Triatoma infestans.Parasites & vectors · 2026Article
- Rhodnius prolixus impairs Trypanosoma cruzi growth through cold-seeking behavioral thermoregulation.PLoS neglected tropical diseases · 2025Article
- Regulation and Roles of Metacyclogenesis and Epimastigogenesis in the Life Cycle ofPathogens (Basel, Switzerland) · 2025Review
- Lectin Recognition Patterns in the Gut ofMicroorganisms · 2025Article
- Review
- Innate Immunity in Insects: The Lights and Shadows of Phenoloxidase System Activation.International journal of molecular sciences · 2025Review
- Effects of fasting on the interplay between temperature and Trypanosoma cruzi infection on the life cycle of the Chagas disease vector Rhodnius prolixus.PLoS neglected tropical diseases · 2024Article
- Interaction ofMicroorganisms · 2024Review
- The interplay between temperature, Trypanosoma cruzi parasite load, and nutrition: Their effects on the development and life-cycle of the Chagas disease vector Rhodnius prolixus.PLoS neglected tropical diseases · 2024Article
- Phenological Shifts in a Warming World Affect Physiology and Life History in a Damselfly.Insects · 2022Article
- Higher temperatures reduce the number of Trypanosoma cruzi parasites in the vector Triatoma pallidipennis.Parasites & vectors · 2021Article
- The holobiont transcriptome of teneral tsetse fly species of varying vector competence.BMC genomics · 2021Article
- An Update on the Knowledge of Parasite-Vector Interactions of Chagas Disease.Research and reports in tropical medicine · 2021Review
- Article
- Slight temperature changes cause rapid transcriptomic responses in Trypanosoma cruzi metacyclic trypomastigotes.Parasites & vectors · 2020Article
- The Influence of Environmental Cues on the Development ofFrontiers in cellular and infection microbiology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLittle is known about how human disease vectors will modify their life history patterns and survival capacity as a result of climate change. One case is that of Chagas disease, which has triatomine bugs and Trypanosoma cruzi as vectors and parasite, respectively. This work aimed to determine: (i) the activity of the prophenoloxidase system (prophenoloxidase and phenoloxidase activity, two indicators of immune ability) in three intestine regions (anterior midgut, posterior midgutand rectum) of the triatomine bug Meccus pallidipennis under three temperature conditions (20 °C, 30 °C and 34 °C) against two T. cruzi strains [ITRI/MX/14/CHIL (Chilpancingo) and ITRI/MX/12/MOR (Morelos)], and (ii) whether vector survival varies under these three temperatures after infection by these T. cruzi strains.
resultsOur results indicate that prophenoloxidase activity was lower at higher temperatures, that the level of prophenoloxidase activity elicited by each strain was different (higher in Chilpancingo than in Morelos strains), and that prophenoloxidase activity was more intense in the anterior midgut than in the posterior midgut or rectum. Survival rates were lower in insects maintained at higher temperatures and infected by Chilpancingo strains.
conclusionsThese results indicate that climate change could lead to lower prophenoloxidase activity and survival rates in triatomines when infected with different T. cruzi strains, which could reduce the vector capacity of M. pallidipennis.
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