Evidence map›Paper›PMID 31068215›Full record

ArticleCritical care (London, England)2019

Renal function after out-of-hospital cardiac arrest; the influence of temperature management and coronary angiography, a post hoc study of the target temperature management trial.

Malin Rundgren, Susann Ullén, Matt P G Morgan, Guy Glover, Julius Cranshaw, Nawaf Al-Subaie, Andrew Walden, Michael Joannidis, Marlies Ostermann, Josef Dankiewicz and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01020916 (Target Temperature Management 33°C Versus 36°C After Out-of-hospital Cardiac Arrest, a Randomised, Parallel Groups, Assessor Blinded Clinical Trial), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01020916 nacompletednot on this map

Target Temperature Management 33°C Versus 36°C After Out-of-hospital Cardiac Arrest, a Randomised, Parallel Groups, Assessor Blinded Clinical Trial

TypeinterventionalSponsorNiklas NielsenRan2010 to 2013Enrolled950ConditionsOut-of-hospital Cardiac ArrestArmsTarget temperature 36°C, Target Temperature 33°C
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Review
  4. Article
  5. Acute kidney injury after out-of-hospital cardiac arrest.Critical care (London, England) · 2024
    Article
  6. Article
  7. Article
  8. Non-Occlusive Mesenteric Ischemia in Cardiac Arrest Patients.Reviews in cardiovascular medicine · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Evaluating NephrocheckInternational journal of nephrology and renovascular disease · 2020
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Malin RundgrenDepartment of Clinical Sciences, Anaesthesia and Intensive Care, Skane University Hospital, Lund University, 221 85, Lund, Sweden. malinrundgren@skane.se.ORCID http://orcid.org/0000-0003-2465-3826
Susann UllénFoprum South, Skane University Hospital, Lund, Sweden.
Matt P G MorganHonorary Research Fellow, Cardiff University School of Medicine, Cardiff, UK.
Guy GloverDepartment of Intensive Care, Guys and St Thomas' Hospital, Kings College London, London, UK.
Julius CranshawDepartment of Anaesthetics and Intensive Care Medicine, Royal Bournemouth Hospital, Bournemouth, UK.
Nawaf Al-SubaieAdult Intensive Care Directorate, St George's Hospital London, London, UK.
Andrew WaldenDepartment of Intensive Care Medicine, Royal Berkshire Hospital, Reading, UK.
Michael JoannidisDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
Marlies OstermannDepartment of Critical Care and Nephrology, Guy's and St Thomas' Hospital, King's College London, London, UK.
Josef DankiewiczDepartment of Cardiology, Skane University Hospital, Lund University, Lund, Sweden.
Niklas NielsenDepartment of Anaesthesia and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden.
Matthew P WiseAdult Critical Care, University Hospital of Wales, Cardiff, UK.

Funding

AFA Försäkring UnknownHans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research unknownHjärt-Lungfonden unkonownKrapperup Foundation unknownregional research support, Region Skåne; government funding of clinical research within the Swedish National Health Services unknownSkåne University Hospital, Sweden unknownthe European Clinical Research Infrastructures Network Unknownthe European Critical Care Research Network unknownThelma Zoega Foundation unknownthe Ministry of Higher Education and Research of Luxembourg Unknownthe National Research Fund, Luxembourg UnknownThure Carlsson Foundation UnknownTrygFonden, Denmark unknownVetenskapsrådet unknown
6 · The paper itself

Abstract

backgroundTo elucidate the incidence of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) and to examine the impact of target temperature management (TTM) and early coronary angiography on renal function.

methodsPost hoc analysis of the TTM trial, a multinational randomised controlled trial comparing target temperature of 33 °C versus 36 °C in patients with return of spontaneous circulation after OHCA. The impact of TTM and early angiography (within 6 h of OHCA) versus late or no angiography on the development of AKI during the 7-day period after OHCA was analysed. AKI was defined according to modified KDIGO criteria in patients surviving beyond day 2 after OHCA.

resultsFollowing exclusions, 853 of 939 patients enrolled in the main trial were analysed. Unadjusted analysis showed that significantly more patients in the 33 °C group had AKI compared to the 36 °C group [211/431 (49%) versus 170/422 (40%) p = 0.01], with a worse severity (p = 0.018). After multivariable adjustment, the difference was not significant (odds ratio 0.75, 95% confidence interval 0.54-1.06, p = 0.10]. Five hundred seventeen patients underwent early coronary angiography. Although the unadjusted analysis showed less AKI and less severe AKI in patients who underwent early angiography compared to patients with late or no angiography, in adjusted analyses, early angiography was not an independent risk factor for AKI (odds ratio 0.73, 95% confidence interval 0.50-1.05, p = 0.09).

conclusionsIn OHCA survivors, TTM at 33 °C compared to management at 36 °C did not show different rates of AKI and early angiography was not associated with an increased risk of AKI.

trial registrationNCT01020916 . Registered on www.ClinicalTrials.gov 26 November 2009 (main trial).

Indexed as

Acute Kidney InjuryAgedCoronary AngiographyFemaleHumansHypothermia, InducedIncidenceLogistic ModelsMaleMiddle AgedOut-of-Hospital Cardiac ArrestPercutaneous Coronary InterventionRetrospective StudiesRisk FactorsStatistics, NonparametricSurvivorsAcute kidney injuryAngiographyContrastInduced hypothermia (target temperature management)Out-of-hospital cardiac arrest

Identifiers

PMID31068215
PMCPMC6506949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.