Evidence map›Paper›PMID 31068081›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Classifying intracranial stenosis disease severity from functional MRI data using machine learning.

Spencer L Waddle, Meher R Juttukonda, Sarah K Lants, Larry T Davis, Rohan Chitale, Matthew R Fusco, Lori C Jordan, Manus J Donahue

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  4. Article
  5. Article
  6. Article
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  8. Article
  9. Choroid plexus perfusion in sickle cell disease and moyamoya vasculopathy: Implications for glymphatic flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  10. Article
  11. Review
  12. Hemodynamic impairments within individual watershed areas in asymptomatic carotid artery stenosis by multimodal MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  13. Article
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  15. Choroid plexus perfusion and intracranial cerebrospinal fluid changes after angiogenesis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Spencer L WaddleDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Meher R JuttukondaDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Sarah K LantsDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Larry T DavisDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Rohan ChitaleDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Matthew R FuscoDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Lori C JordanDepartment of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Manus J DonahueDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Imaging collaterals and tissue metabolism in patients with Moyamoya syndromeR01NS097763 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DONAHUE, MANUS J · 2016 to 2020
$1.7M
MRI-based quantitative brain oxygen metabolism identifying high risk of infarct recurrence in sickle cell anemiaR01NS096127 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JORDAN, LORI CHAFFIN · 2016 to 2020
$1.7M
Characterizing Hemodynamic Compensation and Stroke Risk in Stenosis PatientsR01NS078828 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DONAHUE, MANUS J · 2012 to 2016
$1.6M
Institutional Predoctoral Training Program in Biomedical Imaging ScienceT32EB014841 · NIBIB · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2013 to 2017
$771k
Mentoring in Patient-Oriented Research focused on Neurological Complications of Sickle Cell DiseaseK24HL147017 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JORDAN, LORI CHAFFIN · 2019 to 2023
$547k
NHLBI NIH HHS K24 HL147017NIBIB NIH HHS T32 EB014841NICHD NIH HHS P50 HD103537NICHD NIH HHS U54 HD083211NINDS NIH HHS R01 NS078828NINDS NIH HHS R01 NS096127NINDS NIH HHS R01 NS097763
6 · The paper itself

Abstract

Translation of many non-invasive hemodynamic MRI methods to cerebrovascular disease patients has been hampered by well-known artifacts associated with delayed blood arrival times and reduced microvascular compliance. Using machine learning and support vector machine (SVM) algorithms, we investigated whether arrival time-related artifacts in these methods could be exploited as novel contrast sources to discriminate angiographically confirmed stenotic flow territories. Intracranial steno-occlusive moyamoya patients (

Indexed as

Cerebrovascular CirculationImage Processing, Computer-AssistedMachine LearningBrainCase-Control StudiesCerebral AngiographyFemaleHumansMagnetic Resonance AngiographyMiddle AgedMoyamoya DiseaseSensitivity and SpecificitySeverity of Illness IndexYoung Adultcerebral blood flowcerebrovascular diseasecerebrovascular reactivitymachine learningmoyamoyaStroke

Identifiers

PMID31068081
PMCPMC7168799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.