Evidence map›Paper›PMID 31068047›Full record

ArticleInnate immunity2019

Immunophenotypic, cytotoxic, proteomic and genomic characterization of human cord blood vs. peripheral blood CD56

Evan Shereck, Nancy S Day, Aradhana Awasthi, Janet Ayello, Yaya Chu, Catherine McGuinn, Carmella van de Ven, Megan S Lim, Mitchell S Cairo

Open access · goldAbstract read
In one paragraph

Article in Innate immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Evan Shereck1 Department of Pediatrics, Oregon Health and Science University, Portland, 97239, USA.
Nancy S Day2 Department of Pediatrics, Columbia University, New York, USA.
Aradhana Awasthi3 Department of Pediatrics, New York Medical College, Valhalla, USA.
Janet Ayello3 Department of Pediatrics, New York Medical College, Valhalla, USA.
Yaya Chu3 Department of Pediatrics, New York Medical College, Valhalla, USA.
Catherine McGuinn2 Department of Pediatrics, Columbia University, New York, USA.
Carmella van de Ven3 Department of Pediatrics, New York Medical College, Valhalla, USA.
Megan S Lim4 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA.
Mitchell S Cairo3 Department of Pediatrics, New York Medical College, Valhalla, USA.ORCID 0000-0002-2075-434X
New York Medical College · USColumbia University · USOregon Health & Science University · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unrelated cord blood (CB) is an excellent alternative as an allogeneic donor source for stem cell transplantation. CB transplantation is associated with lower incidence of severe acute graft versus host disease (GVHD) and chronic GVHD but similar rates of malignant relapse compared with other unrelated donor cell transplants. NK cells are critical innate immune components and the comparison of CB vs. peripheral blood (PB) NK cells is relatively unknown. NK cell receptor expression, cell function, and maturation may play a role in the risk of relapse after CB transplant. We investigated CB vs. PB NK cell subset cytotoxicity, function, receptor expression, and genomic and proteomic signatures. The CB CD56

Indexed as

AdultApoptosisCD56 AntigenCell Line, TumorCytotoxicity, ImmunologicFetal BloodGenomicsHumansImmunophenotypingKiller Cells, NaturalNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily KProteomicsReceptors, NK Cell Lectin-LikeSignal TransductionTranscriptomeCD56 AntigenKLRC1 protein, humanKLRK1 protein, humanNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily KReceptors, NK Cell Lectin-LikeCD56cord bloodgenomicsinnate immunityNK cells

Identifiers

PMID31068047
PMCPMC6830905
OpenAlexW2944188948

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.