Evidence map›Paper›PMID 31068035›Full record

Observational studyThe Journal of international medical research2019

Association between anti-α-1,4-D-polygalacturonic acid antibodies and Henoch-Schönlein purpura in children.

Meihua Miao, Xiaozhong Li, Qin Wang, Yunfen Zhu, Yanyan Cui, Xuejun Shao

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meihua Miao1 Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Xiaozhong Li1 Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Qin Wang2 Department of Immunology, School of Biology and Basic Medical Science, Soochow University, Suzhou, China.
Yunfen Zhu1 Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Yanyan Cui1 Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Xuejun Shao1 Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0002-4853-2634
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the relationship between anti-α-1,4-D-polygalacturonic acid (PGA) antibodies, particularly immunoglobulin (Ig)A, and Henoch-Schönlein purpura (HSP) in children.

methodsThis observational case-control study investigated PGA-IgA, PGA-IgG, and PGA/PGA-IgA circulating immune complex (PGA/PGA-IgA CIC) in paediatric patients with HSP versus controls. Children with HSP were also evaluated for food specific IgG and food intolerance. Between-group differences in anti-PGA antibodies were analysed.

resultsSerum PGA-IgA and PGA-IgG levels were significantly increased in patients with acute HSP ( n = 251) versus those with urticaria ( n = 48), acute respiratory infections ( n = 95), surgical controls ( n = 53) and neonates ( n = 92). PGA/PGA-IgA CIC levels were also significantly higher in the acute HSP group versus surgical control and neonate groups. Levels of PGA/PGA-IgA CIC and PGA-IgA were significantly correlated ( r = 0.997), and PGA-IgA showed high diagnostic specificity for HSP. No statistically significant differences were observed in PGA-IgA and PGA-IgG between various degrees of food intolerance in children with HSP.

conclusionIncreased anti-PGA antibodies, particularly PGA-IgA and PGA/PGA-IgA CIC, were significantly associated with acute HSP in children. Food intolerance was not found to be associated with increased anti-PGA antibodies in children with HSP.

Indexed as

AdolescentAutoantibodiesCase-Control StudiesChildChild, PreschoolFemaleHumansIgA VasculitisImmunoglobulin AImmunoglobulin GInfantMalePectinsPrognosisAutoantibodiesImmunoglobulin AImmunoglobulin GPectinspolygalacturonic acidChildrenHenoch-Schönlein purpuraimmunologyα-1,4-D-polygalacturonic acid antibody

Identifiers

PMID31068035
PMCPMC6567704
OpenAlexW2944683865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.