Evidence map›Paper›PMID 31067786›Full record

ArticleMarine drugs2019

The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium.

Tânia Keiko Shishido, Jouni Jokela, Anu Humisto, Suvi Suurnäkki, Matti Wahlsten, Danillo O Alvarenga, Kaarina Sivonen, David P Fewer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Natural Products That Contain Higher Homologated Amino Acids.Chembiochem : a European journal of chemical biology · 2024
    Review
  6. Article
  7. Article
  8. Current research scenario for biological effect of exogenous factors on microcystin synthesis.Environmental science and pollution research international · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Frontiers in plant science · 2020
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tânia Keiko ShishidoDepartment of Microbiology, University of Helsinki, Viikinkaari 9, FI-0014 Helsinki, Finland. tania.shishido@helsinki.fi.
Jouni JokelaDepartment of Microbiology, University of Helsinki, Viikinkaari 9, FI-0014 Helsinki, Finland. jouni.jokela@helsinki.fi.
Anu HumistoDepartment of Microbiology, University of Helsinki, Viikinkaari 9, FI-0014 Helsinki, Finland. anu.humisto@helsinki.fi.
Suvi SuurnäkkiDepartment of Microbiology, University of Helsinki, Viikinkaari 9, FI-0014 Helsinki, Finland. matti.wahlsten@helsinki.fi.
Matti WahlstenDepartment of Microbiology, University of Helsinki, Viikinkaari 9, FI-0014 Helsinki, Finland. matti.wahlsten@helsinki.fi.
Danillo O AlvarengaDepartment of Microbiology, University of Helsinki, Viikinkaari 9, FI-0014 Helsinki, Finland. danillo.oliveiradealvarenga@helsinki.fi.
Kaarina SivonenDepartment of Microbiology, University of Helsinki, Viikinkaari 9, FI-0014 Helsinki, Finland. kaarina.sivonen@helsinki.fi.
David P FewerDepartment of Microbiology, University of Helsinki, Viikinkaari 9, FI-0014 Helsinki, Finland. david.fewer@helsinki.fi.
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microcystins are a family of chemically diverse hepatotoxins produced by distantly related cyanobacteria and are potent inhibitors of eukaryotic protein phosphatases 1 and 2A. Here we provide evidence for the biosynthesis of rare variants of microcystin that contain a selection of homo-amino acids by the benthic strain

Indexed as

Amino AcidsAmino Acid SequenceBacterial ProteinsCyanobacteriaGenes, BacterialMicrocystinsMultigene FamilyPhylogenyProtein Interaction Domains and MotifsSequence Analysis, DNAAmino AcidsBacterial ProteinsMicrocystinsadenylation domaincyanobacteriahepatotoxinmass spectrometrynonribosomal peptide synthetase (NRPS)polyketide synthase (PKS)

Identifiers

PMID31067786
PMCPMC6562525
OpenAlexW2944738147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.