Evidence map›Paper›PMID 31067782›Full record

ArticlePharmaceutics2019

Thermally-Responsive Loading and Release of Elastin-Like Polypeptides from Contact Lenses.

Wan Wang, Changrim Lee, Martha Pastuszka, Gordon W Laurie, J Andrew MacKay

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Targeting Iron - Respiratory Reciprocity Promotes Bacterial Death.bioRxiv : the preprint server for biology · 2024
    Article
  3. Seeing the Future: A Review of Ocular Therapy.Bioengineering (Basel, Switzerland) · 2024
    Review
  4. Review
  5. Protein and polypeptide mediated delivery to the eye.Advanced drug delivery reviews · 2022
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wan WangDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA. leilawangwan@gmail.com.
Changrim LeeDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA. changril@usc.edu.
Martha PastuszkaDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA. martha.past@gmail.com.
Gordon W LaurieDepartment of Cell Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. gwl6s@virginia.edu.
J Andrew MacKayDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA. jamackay@usc.edu.
University of Southern California · USUniversity of Virginia · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
Protein-polymer nanomedicine for Sjogren's SyndromeR01EY026635 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sarah F Hamm-Alvarez, John Andrew MacKay · 2017 to 2026
$4.6M
Tear Protein Microbial RegulationR01EY026171 · NEI · UNIVERSITY OF VIRGINIA · PI LAURIE, GORDON WILLIAM · 2016 to 2025
$3.6M
Intracellular switching using genetically engineered protein microdomainsR01GM114839 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACKAY, JOHN ANDREW · 2015 to 2019
$1.9M
Lacritin Regulated Ocular Surface HomeostasisR01EY024327 · NEI · UNIVERSITY OF VIRGINIA · PI LAURIE, GORDON WILLIAM · 2014 to 2017
$1.8M
A rapid, reversible switch for controlling intracellular traffickingR21EB012281 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACKAY, JOHN ANDREW · 2010 to 2011
$438k
Medical Research and Materiel Command 11262019NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY024327NEI NIH HHS R01 EY026171NIH HHS P30CA014089NIH HHS P30EY029220NIH HHS R01EY024327NIH HHS R01EY026171NIH HHS R01EY026635NIH HHS R01GM114839NIH HHS R21EB012281
6 · The paper itself

Abstract

Contact lenses are widely prescribed for vision correction, and as such they are an attractive platform for drug delivery to the anterior segment of the eye. This manuscript explores a novel strategy to drive the reversible adsorption of peptide-based therapeutics using commercially available contact lenses. To accomplish this, thermo-sensitive elastin-like polypeptides (ELPs) alone or tagged with a candidate ocular therapeutic were characterized. For the first time, this manuscript demonstrates that Proclear Compatibles

Indexed as

contact lensdrug deliveryelastin-like polypeptide (ELPs)lacritinprotein therapeutics

Identifiers

PMID31067782
PMCPMC6572635
OpenAlexW2944239531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.