ArticleToxins2019
Varanid Lizard Venoms Disrupt the Clotting Ability of Human Fibrinogen through Destructive Cleavage.
Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Histological and histochemical characterisation of the salivary glands of the palatine fold and the mandibular venom gland of the Komodo dragon (Varanus komodoensis).Veterinary research communications · 2025Article
- Venom exaptation and adaptation during the trophic switch to blood-feeding by kissing bugs.iScience · 2024Article
- The Clot Thickens: Differential Coagulotoxic and Cardiotoxic Activities of Anguimorpha Lizard Venoms.Toxins · 2024Article
- Private Keeping of Dangerous Wild Animals in Great Britain.Animals : an open access journal from MDPI · 2024Article
- A Russian Doll of Resistance: Nested Gains and Losses of Venom Immunity in Varanid Lizards.International journal of molecular sciences · 2024Article
- Function Prediction of Peptide Toxins with Sequence-Based Multi-Tasking PU Learning Method.Toxins · 2022Article
- Dynamic genetic differentiation drives the widespread structural and functional convergent evolution of snake venom proteinaceous toxins.BMC biology · 2022Article
- Neglected Venomous Animals and Toxins: Underrated Biotechnological Tools in Drug Development.Toxins · 2021Review
- Article
- Beware of the Dragon: A Case Report of a Komodo Dragon Attack.Foot & ankle orthopaedics · 2021Article
- The Curious Case of the "Neurotoxic Skink": Scientific Literature Points to the Absence of Venom in Scincidae.Toxins · 2021Article
- A Clot Twist: Extreme Variation in Coagulotoxicity Mechanisms in Mexican Neotropical Rattlesnake Venoms.Frontiers in immunology · 2021Article
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- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functional activities of Anguimorpha lizard venoms have received less attention compared to serpent lineages. Bite victims of varanid lizards often report persistent bleeding exceeding that expected for the mechanical damage of the bite. Research to date has identified the blockage of platelet aggregation as one bleeding-inducing activity, and destructive cleavage of fibrinogen as another. However, the ability of the venoms to prevent clot formation has not been directly investigated. Using a thromboelastograph (TEG5000), clot strength was measured after incubating human fibrinogen with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.