Evidence map›Paper›PMID 31067756›Full record

ArticleInternational journal of environmental research and public health2019

Molecular Study of Thyroid Cancer in World Trade Center Responders.

Maaike A G van Gerwen, Stephanie Tuminello, Gregory J Riggins, Thais B Mendes, Michael Donovan, Emma K T Benn, Eric Genden, Janete M Cerutti, Emanuela Taioli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. World Trade Center Health Program: First Decade of Research.International journal of environmental research and public health · 2020
    Review
  8. Article
  9. Editorial for "Long-Term Health Effects of the 9/11 Disaster" inInternational journal of environmental research and public health · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Maaike A G van GerwenInstitute for Translational Epidemiology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. maaike.vangerwen@icahn.mssm.edu.ORCID 0000-0002-0568-7388
Stephanie TuminelloInstitute for Translational Epidemiology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. stephanie.tuminello@mssm.edu.
Gregory J RigginsDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA. griggin1@jhmi.edu.
Thais B MendesDivision of Genetics, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil. thais_biude@hotmail.com.
Michael DonovanDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. michael.donovan@mssm.edu.
Emma K T BennDepartment of Population Health Science and Policy, Center for Biostatistics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. emma.benn@mountsinai.org.
Eric GendenDepartment of Otolaryngology- Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Eric.Genden@mountsinai.org.
Janete M CeruttiDivision of Genetics, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil. j.cerutti@unifesp.br.
Emanuela TaioliInstitute for Translational Epidemiology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. emanuela.taioli@mountsinai.org.
Icahn School of Medicine at Mount Sinai · USUniversidade Federal de São Paulo · BRJohns Hopkins University · US

Funding

Thyroid cancer risk in WTC respondersU01OH010984 · OH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RIGGINS, GREGORY JOSEPH, TAIOLI, EMANUELA · 2016 to 2018
$1.5M
NIOSH CDC HHS 1U01OH010984-01A1NIOSH CDC HHS U01 OH010984NIOSH CDC HHS U01 OH011704
6 · The paper itself

Abstract

Thyroid cancer incidence is higher in World Trade Center (WTC) responders compared with the general population. It is unclear whether this excess in thyroid cancer is associated with WTC-related exposures or if instead there is an over-diagnosis of malignant thyroid cancer among WTC first responders due to enhanced surveillance and physician bias. To maximize diagnostic yield and determine the false positive rate for malignancy, the histological diagnoses of thyroid cancer tumors from WTC responders and age, gender, and histology matched non-WTC thyroid cancer cases were evaluated using biomarkers of malignancy. Using a highly accurate panel of four biomarkers that are able to distinguish benign from malignant thyroid cancer, our results suggest that over-diagnosis by virtue of misdiagnosis of a benign tumor as malignant does not explain the increased incidence of thyroid cancer observed in WTC responders. Therefore, rather than over-diagnosis due to physician bias, the yearly screening visits by the World Trade Center Health Program are identifying true cases of thyroid cancer. Continuing regular screening of this cohort is thus warranted.

Indexed as

September 11 Terrorist AttacksThyroid NeoplasmsAdultBiomarkersCohort StudiesDiagnostic ErrorsEmergency RespondersFemaleHumansIncidenceMaleMiddle AgedPrejudiceBiomarkers9/11biomarkersscreeningthyroid cancer

Identifiers

PMID31067756
PMCPMC6539993
OpenAlexW2944627647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.