Evidence map›Paper›PMID 31067753›Full record

ArticleInternational journal of molecular sciences2019

Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine.

David Ramírez, Mauricio Bedoya, Aytug K Kiper, Susanne Rinné, Samuel Morales-Navarro, Erix W Hernández-Rodríguez, Francisco V Sepúlveda, Niels Decher, Wendy González

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. 5-(Indol-2-yl)pyrazolo[3,4-Molecules (Basel, Switzerland) · 2021
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

David RamírezInstituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile. El Llano Subercaseaux 2801-Piso 6, 7500912 Santiago, Chile. david.ramirez@uautonoma.cl.ORCID 0000-0003-0002-1189
Mauricio BedoyaCentro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca. 1 Poniente No. 1141, 3460000 Talca, Chile. maurobedoyat@gmail.com.ORCID 0000-0002-3542-7528
Aytug K KiperInstitute for Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany. aytug.kiper@staff.uni-marburg.de.
Susanne RinnéInstitute for Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany. rinne@staff.uni-marburg.de.
Samuel Morales-NavarroBachillerato en Ciencias, Facultad de Ciencias, Universidad Santo Tomás, Av. Circunvalación Poniente #1855, 3460000 Talca, Chile. smoralesn@santotomas.cl.
Erix W Hernández-RodríguezCentro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca. 1 Poniente No. 1141, 3460000 Talca, Chile. erhernandez@utalca.cl.ORCID 0000-0002-9231-7552
Francisco V SepúlvedaCentro de Estudios Científicos (CECs), Arturo Prat 514, 5110000 Valdivia, Chile. fsepulveda@cecs.cl.
Niels DecherInstitute for Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany. decher@staff.uni-marburg.de.
Wendy GonzálezCentro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca. 1 Poniente No. 1141, 3460000 Talca, Chile. wgonzalez@utalca.cl.ORCID 0000-0002-7535-6883
Philipps University of Marburg · DEUniversity of Talca · CLCentro de Estudios Científicos · CLUniversidad Autónoma de Chile · CLUniversidad Santo Tomás · CL

Funding

Deutsche Forschungsgemeinschaft DE1482-4/1Fondo Nacional de Desarrollo Científico y Tecnológico 11180604Fondo Nacional de Desarrollo Científico y Tecnológico 1140624Fondo Nacional de Desarrollo Científico y Tecnológico 1191133Millennium Nucleus of Ion Channels Associated Diseases MiNICAD
6 · The paper itself

Abstract

TASK-3 potassium (K

Indexed as

Molecular Docking SimulationAnimalsBinding SitesHumansPotassium Channel BlockersPotassium Channels, Tandem Pore DomainProtein BindingPyridinesPyrimidinesXenopusKCNK9 protein, humanPotassium Channel BlockersPotassium Channels, Tandem Pore DomainPyridinesPyrimidinestetrahydropyrido(4,3-d)pyrimidine5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine derivativesdrug-protein interactionmolecular dockingmolecular dynamicsmutagenesis screenPK-THPPTASK-3 channelTASK channels blockers

Identifiers

PMID31067753
PMCPMC6539479
OpenAlexW2944126436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.