Evidence map›Paper›PMID 31067690›Full record

ReviewMolecules (Basel, Switzerland)2019

Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest.

Raúl J Gazmuri, Jeejabai Radhakrishnan, Iyad M Ayoub

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Improvement of Cardiac Function by Polyclonal Antibodies Against CaInternational journal of molecular sciences · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. The Remaining Conundrum of the Role of the NaReviews in cardiovascular medicine · 2022
    Review
  11. NaPharmaceuticals (Basel, Switzerland) · 2022
    Review
  12. Review
  13. Myocardial Impact of NHE1 Regulation by Sildenafil.Frontiers in cardiovascular medicine · 2021
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Raúl J GazmuriResuscitation Institute, Rosalind Franklin University of Medicine and Science, Section of Critical Care Medicine, Captain James A. Lovell Federal Health Care Center, North Chicago, IL 60064, USA. raul.gazmuri@rosalindfranklin.edu.ORCID 0000-0002-3848-7227
Jeejabai RadhakrishnanResuscitation Institute, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA. jeejabai.radhakrishnan@rosalindfranklin.edu.
Iyad M AyoubResuscitation Institute, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA. iyad.ayoub@rosalindfranklin.edu.
Rosalind Franklin University of Medicine and Science · US

Funding

National Institutes of Health R01HL071728
6 · The paper itself

Abstract

Out-of-hospital sudden cardiac arrest is a major public health problem with an overall survival of less than 5%. Upon cardiac arrest, cessation of coronary blood flow rapidly leads to intense myocardial ischemia and activation of the sarcolemmal Na

Indexed as

CalciumCalcium SignalingHeart ArrestHumansModels, AnimalMyocardial IschemiaMyocardiumMyocytes, CardiacSarcolemmaSodium-Hydrogen ExchangersVentricular FibrillationCalciumgrowth factor-activatable Na-H exchanger NHE-1Sodium-Hydrogen Exchangerscardiopulmonary resuscitationenergy metabolismischemiamitochondriamyocardiumreperfusion injurysodium calcium exchangersudden cardiac arrestventricular function

Identifiers

PMID31067690
PMCPMC6538998
OpenAlexW2944278051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.