Evidence map›Paper›PMID 31067669›Full record

ArticleInternational journal of molecular sciences2019

Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence-A Transcriptomic Study.

Błażej Chermuła, Maciej Brązert, Michal Jeseta, Katarzyna Ożegowska, Ievgenia Kocherova, Maurycy Jankowski, Piotr Celichowski, Patrycja Sujka-Kordowska, Aneta Konwerska, Hanna Piotrowska-Kempisty and 10 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Błażej ChermułaDivision of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, 60-535 Poznań, Poland. blazej.chermula@wp.pl.
Maciej BrązertDivision of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, 60-535 Poznań, Poland. maciejbrazert@ump.edu.pl.
Michal JesetaDepartment of Obstetrics and Gynecology, University Hospital and Masaryk University, 601 77 Brno, Czech Republic. jeseta@gmail.com.ORCID 0000-0003-1778-3454
Katarzyna OżegowskaDivision of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, 60-535 Poznań, Poland. katarzyna.ozegowska@ump.edu.pl.
Ievgenia KocherovaDepartment of Anatomy, Poznan University of Medical Sciences, 60-781 Poznań, Poland. kocherova.evgenia@gmail.com.ORCID 0000-0003-2561-9750
Maurycy JankowskiDepartment of Anatomy, Poznan University of Medical Sciences, 60-781 Poznań, Poland. m.jankowski.14@aberdeen.ac.uk.ORCID 0000-0001-9476-0235
Piotr CelichowskiDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznań, Poland. p.celichowski@gmail.com.
Patrycja Sujka-KordowskaDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznań, Poland. psujka@ump.edu.pl.
Aneta KonwerskaDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznań, Poland. akonwer@ump.edu.pl.
Hanna Piotrowska-KempistyDepartment of Toxicology, Poznan University of Medical Sciences, 61-631 Poznań, Poland. hpiotrow@ump.edu.pl.
Joanna Budna-TukanDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznań, Poland. joanna.budna@wp.pl.
Paweł AntosikVeterinary Center, Nicolaus Copernicus University in Torun, 87-100 Toruń, Poland. pantosik@umk.pl.
Dorota BukowskaVeterinary Center, Nicolaus Copernicus University in Torun, 87-100 Toruń, Poland. dbukowska@umk.pl.
Marie MachatkovaVeterinary Research Institute, 621 00 Brno, Czech Republic. machatkova@vri.cz.
Klaus P BrussowVeterinary Center, Nicolaus Copernicus University in Torun, 87-100 Toruń, Poland. prof.bruessow@gmail.com.
Mariusz T SkowrońskiVeterinary Center, Nicolaus Copernicus University in Torun, 87-100 Toruń, Poland. skowron@uwm.edu.pl.ORCID 0000-0003-2775-9642
Leszek PawelczykDivision of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, 60-535 Poznań, Poland. pawelczyk.leszek@ump.edu.pl.
Małgorzata BruskaDepartment of Anatomy, Poznan University of Medical Sciences, 60-781 Poznań, Poland. mbruska@ump.edu.pl.
Michał NowickiDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznań, Poland. mnowicki@ump.edu.pl.
Bartosz KempistyDepartment of Obstetrics and Gynecology, University Hospital and Masaryk University, 601 77 Brno, Czech Republic. bkempisty@ump.edu.pl.

Funding

Narodowe Centrum Nauki UMO-2016/21/B/NZ9/03535
6 · The paper itself

Abstract

This paper aims to identify and describe new genetic markers involved in the processes of protein expression and modification reflected in the change of mitochondrial activity before and after in vitro maturation of the oocyte. Porcine oocytes collected from the ovaries of slaughtered landrace gilts were subjected to the process of in vitro maturation. Transcriptomic changes in the expression profile of oocyte genes involved in response to hypoxia, the transmembrane protein receptor serine threonine kinase signaling pathway, the "transforming growth factor β receptor signaling pathway", "response to protein stimulus", and "response to organic substance" were investigated using microarrays. The expression values of these genes in oocytes was analyzed before (immature) and after (mature) in vitro maturation, with significant differences found. All the significantly altered genes showed downregulation after the maturation process. The most changed genes from these gene ontologies,

Indexed as

TranscriptomeAnimalsCell HypoxiaCells, CulturedFemaleIn Vitro Oocyte Maturation TechniquesMitochondriaOocytesOogenesisReceptor Protein-Tyrosine KinasesSignal TransductionSwineTransforming Growth Factor betaReceptor Protein-Tyrosine KinasesTransforming Growth Factor betamicroarraymitochondrial activityoocyte maturationpig

Identifiers

PMID31067669
PMCPMC6539048

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.