Evidence map›Paper›PMID 31067609›Full record

ArticleKidney research and clinical practice2019

Fracture risk in chronic kidney disease: A Korean population-based cohort study.

Young Eun Kwon, Hyung Yun Choi, Sol Kim, Dong-Ryeol Ryu, Hyung Jung Oh, ESRD Registry Committee of the Korean Society of Nephrology

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney research and clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Serum phosphate is associated with increased risk of bone fragility fractures in haemodialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Observational
  6. Review
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  8. Review
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  13. Is dual-energy absorptiometry accurate in the assessment of bone status of patients with chronic kidney disease?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Article
  14. Article
  15. Article
  16. The clinical impact of gut microbiota in chronic kidney disease.The Korean journal of internal medicine · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Young Eun KwonDepartment of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.ORCID http://orcid.org/0000-0002-0843-9857
Hyung Yun ChoiThe Korean Society of Nephrology, Seoul, Korea.ORCID http://orcid.org/0000-0002-6134-3504
Sol KimDepartment of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.ORCID http://orcid.org/0000-0002-7969-0934
Dong-Ryeol RyuDepartment of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.ORCID http://orcid.org/0000-0002-5309-7606
Hyung Jung OhEwha Institute of Convergence Medicine and Research Institute for Human Health Information, Ewha Womans University, Seoul, Korea.ORCID http://orcid.org/0000-0002-4281-696X
ESRD Registry Committee of the Korean Society of Nephrology
Ewha Womans University · KRMyongji Hospital · KRThe Korean Society of Nephrology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD)-mineral and bone disorder (MBD) and fracture risk are both closely related to declining renal function. Controlling hyperphosphatemia with phosphate binders is a basic principle of CKD-MBD treatment. The aim of this study was to identify differences in fracture risk between pre-dialysis CKD patients and end-stage renal disease (ESRD) on dialysis, and to evaluate the effects of phosphate binders on fracture risk in ESRD patients.

methodsData from a total of 89,533 CKD patients comprising CKD diagnosis, dialysis, fracture history, and phosphate binder prescription history from 2012 to 2016 were retrieved from the Health Insurance Review and Assessment Service Database. Multivariate Cox regression analyses were performed to identify whether dialysis or phosphate binders were associated with an increased fracture risk.

resultsOverall, the rate of fractures in pre-dialysis CKD patients was 74 per 1,000 patient-years, while that in dialysis patients was 84 per 1,000 patient-years. The risk of fracture in ESRD patients was higher than pre-dialysis CKD patients (hazard ratio, 1.16; 95% confidence interval, 1.12-1.21;

conclusionFractures were more prevalent in ESRD patients on dialysis than pre-dialysis CKD patients. Use of phosphate binders was associated with a lower fracture risk in ESRD patients.

Indexed as

Chronic renal insufficiencyDialysisFracturePhosphate binder

Identifiers

PMID31067609
PMCPMC6577209
OpenAlexW2944315963

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.