Evidence map›Paper›PMID 31067469›Full record

ArticleCell reports2019

Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.

Darienne R Myers, Emilia Norlin, Yvonne Vercoulen, Jeroen P Roose

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Human CD4iScience · 2024
    Article
  10. Acta biochimica et biophysica Sinica · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Regulation of the Small GTPase Ras and Its Relevance to Human Disease.Methods in molecular biology (Clifton, N.J.) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Darienne R MyersDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Emilia NorlinDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Yvonne VercoulenDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Jeroen P RooseDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: jeroen.roose@ucsf.edu.
University of California, San Francisco · US

Funding

Understand the metabolic fitness of naïve T cellsP01AI091580 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JEROEN ROOSE · 2011 to 2026
$31.1M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling VariantsR01AI104789 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROOSE, JEROEN · 2014 to 2018
$1.9M
NIAID NIH HHS P01 AI091580NIAID NIH HHS R01 AI104789NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Naive CD4

Indexed as

Protein BiosynthesisSignal TransductionAnimalsAutoimmunityCell DifferentiationCell LineChickensGuanine Nucleotide Exchange FactorsHumansMechanistic Target of Rapamycin Complex 1Mice, Inbred C57BLMice, TransgenicTh2 CellsT-LymphocytesTOR Serine-Threonine KinasesGuanine Nucleotide Exchange FactorsMechanistic Target of Rapamycin Complex 1Rasgrp1 protein, mouseTOR Serine-Threonine KinasesAnaefautoimmunityCD44CD5mRNA translationmTORnaive T cellRasgrp1ribosome profilingtonic signaling

Identifiers

PMID31067469
PMCPMC6593126
OpenAlexW2944553462

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.