ArticleCell reports2019
High Dietary Sugar Reshapes Sweet Taste to Promote Feeding Behavior in Drosophila melanogaster.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 148 citations in OpenAlex.
- Insulin receptor signaling in gustatory cells suppresses sugar taste sensitivity and feeding iniScience · 2026Article
- Advances and Prospects in Odour-based Management of Filth Flies.Journal of chemical ecology · 2026Review
- dArc1 controls sugar reward valuation in Drosophila melanogaster.Current biology : CB · 2025Article
- From Lab to Clinic and Farm: LeveragingBiology · 2025Review
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- Dietary salt induces taste desensitization via receptor internalization in Drosophila in a sexually dimorphic manner.Molecules and cells · 2025Article
- The impact of sugar diet on humidity preference, survival, and host landing in mosquitoes.Journal of medical entomology · 2025Article
- Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila.Scientific reports · 2025Article
- Brain O-GlcNAcylation: Bridging physiological functions, disease mechanisms, and therapeutic applications.Molecular psychiatry · 2025Review
- Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inbioRxiv : the preprint server for biology · 2025Article
- Taste Plasticity in Nutrition and Health: A Scoping Review.Nutrients · 2025Article
- Experimental Evolution Induced by Maternal Post-copulatory Factors in Drosophila.Behavior genetics · 2025Article
- Age- and oxidative stress-induced centrosome amplification and renal stones in Drosophila Malpighian tubules.Biology open · 2024Article
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- Con-DAM: Simultaneous measurement of food intake and sleep inmicroPublication biology · 2024Article
- Legacies of salient environmental experiences-insights from chemosensation.Chemical senses · 2024Article
- Con-FLIC: concurrent measurement of feeding behaviors and food consumption inmicroPublication biology · 2024Article
- Increased sugar valuation contributes to the evolutionary shift in egg-laying behavior of the fruit pest Drosophila suzukii.PLoS biology · 2023Article
- Fat- and sugar-induced signals regulate sweet and fat taste perception in Drosophila.Cell reports · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 3 countries.
Funding
Abstract
Recent studies find that sugar tastes less intense to humans with obesity, but whether this sensory change is a cause or a consequence of obesity is unclear. To tackle this question, we study the effects of a high sugar diet on sweet taste sensation and feeding behavior in Drosophila melanogaster. On this diet, fruit flies have lower taste responses to sweet stimuli, overconsume food, and develop obesity. Excess dietary sugar, but not obesity or dietary sweetness alone, caused taste deficits and overeating via the cell-autonomous action of the sugar sensor O-linked N-Acetylglucosamine (O-GlcNAc) transferase (OGT) in the sweet-sensing neurons. Correcting taste deficits by manipulating the excitability of the sweet gustatory neurons or the levels of OGT protected animals from diet-induced obesity. Our work demonstrates that the reshaping of sweet taste sensation by excess dietary sugar drives obesity and highlights the role of glucose metabolism in neural activity and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.