Trial reportPloS one2019
Comparison of autonomic stress reactivity in young healthy versus aging subjects with heart disease.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02657382 (Effects of Biofeedback on Myocardial Blood Flow Changes During Mental Stress in Patients With Coronary Artery Disease), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Biofeedback on Myocardial Blood Flow Changes During Mental Stress in Patients With Coronary Artery Disease
Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Quantifying acute physiological biomarkers of transcutaneous cervical vagal nerve stimulation in the context of psychological stress.Brain stimulationTrial
- Multidimensional Fatigue Assessment of High-Altitude Electrical Workers: A Comprehensive Analysis Based on Physiological and Psychological Indicators : Electrical Workers: A Comprehensive Analysis.Applied psychophysiology and biofeedback · 2026Article
- A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder.Journal of affective disorders reports · 2026Article
- Standard deviation of pulse pressure measured using wearable devices improves the estimation of acute psychological stress.Scientific reports · 2025Article
- From Inactivity to Activity: Passive Wheelchair Bike Rides Increase Trapezius Muscle Activity in Non-Ambulant Youth with Disabilities.Children (Basel, Switzerland) · 2025Article
- Autonomic reactivity to mental stress is associated with cardiovascular mortality.European heart journal open · 2024Article
- Comparative Analysis of the Feasibility of Myocardial Blood Flow Index Versus CT-FFR in the Diagnosis of Suspected Coronary Artery Disease.Reviews in cardiovascular medicine · 2024Article
- Cardiac psychophysiological tuning to socioaffective content is disrupted in aged rhesus monkeys (Macaca mulatta).Psychophysiology · 2024Article
- Cardiovascular pathophysiology from the cardioneural perspective and its clinical applications.Trends in cardiovascular medicine · 2022Review
- Relationship Between the Onset of Ménière's Disease and Sympathetic Hyperactivity.Frontiers in neurology · 2022Article
- Article
- Automatic Detection of Target Engagement in Transcutaneous Cervical Vagal Nerve Stimulation for Traumatic Stress Triggers.IEEE journal of biomedical and health informatics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe autonomic response to acute emotional stress can be highly variable, and pathological responses are associated with increased risk of adverse cardiovascular events. We evaluated the autonomic response to stress reactivity of young healthy subjects and aging subjects with coronary artery disease to understand how the autonomic stress response differs with aging.
methodsPhysiologic reactivity to arithmetic stress in a cohort of 25 young, healthy subjects (< 30 years) and another cohort of 25 older subjects (> 55 years) with CAD was evaluated using electrocardiography, impedance cardiography, and arterial pressure recordings. Stress-related changes in the pre-ejection period (PEP), which measures sympathetic activity, and high frequency heart rate variability (HF HRV), which measures parasympathetic activity, were analyzed as primary outcomes.
resultsMental stress reduced PEP in both groups (p<0.01), although the decrease was 50% greater in the healthy group. Mean HF HRV decreased significantly in the aging group only (p = 0.01). DISCUSSION: PEP decreases with stress regardless of health and age status, implying increased sympathetic function. Its decline with stress may be attenuated in CAD. The HF HRV (parasympathetic) stress reactivity is more variable and attenuated in younger individuals; perhaps this is related to a protective parasympathetic reflex.
trial registrationClinicalTrials.gov Identifier: NCT02657382.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.