Evidence map›Paper›PMID 31066786›Full record

ArticleActa cirurgica brasileira2019

Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats.

Hüseyin Eken, Orhan Cimen, Ferda Keskin Cimen, Eray Kurnaz, Murat Yildirim, Volkan Tasova, Nezahat Kurt, Kamil Pehlivanoglu, Didem Onk, Asli Ozbek Bilgin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Hüseyin EkenAssistant Professor, Department of General Surgery, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Scientific, intellectual, conception and design of the study; manuscript preparation.ORCID http://orcid.org/0000-0001-6095-6002
Orhan CimenAssistant Professor, Department of General Surgery, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Conception and design of the study, manuscript preparation.ORCID http://orcid.org/0000-0003-4723-5838
Ferda Keskin CimenAssistant Professor, Department of Pathology, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Histopathological examinations, manuscript writing.ORCID http://orcid.org/0000-0002-1844-0827
Eray KurnazMD, Department of General Surgery, Mengücek Gazi Training and Research Hospital, Erzincan, Turkey. Technical procedures, manuscript preparation.ORCID http://orcid.org/0000-0002-9043-558X
Murat YildirimMD, Department of General Surgery, Zile State Hospital, Tokat, Turkey. Technical procedures, manuscript preparation.ORCID http://orcid.org/0000-0002-4938-5103
Volkan TasovaMD, Department of General Surgery, Sabuncuoglu Serafettin Training and Research Hospital, Amasya University, Turkey. Technical procedures, manuscript preparation.ORCID http://orcid.org/0000-0003-3368-4421
Nezahat KurtPhD, Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey. Acquisition, analysis and interpretation of data; technical procedures.ORCID http://orcid.org/0000-0002-1685-5332
Kamil PehlivanogluAssistant Professor, Department of General Surgery, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Manuscript preparation.ORCID http://orcid.org/0000-0003-2981-3964
Didem OnkAssistant Professor, Department of Anesthesiology and Reanimation, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Technical procedures, critical revision.ORCID http://orcid.org/0000-0001-8849-0531
Asli Ozbek BilginAssistant Professor, Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Statistics analysis, manuscript writing, critical revision, final approval.ORCID http://orcid.org/0000-0001-9027-4299
Erzincan Binali Yıldırım University · TRAmasya Üniversitesi · TRAtatürk University · TRSivas State Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods.

methodsEighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours.

resultsOxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group.

conclusionThe taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCeliac ArteryDisease Models, AnimalGastric MucosaLigationMaleOxidation-ReductionOxidative StressQuercetinRatsRats, WistarReperfusion InjuryAnti-Inflammatory Agents, Non-SteroidalQuercetintaxifolin

Identifiers

PMID31066786
PMCPMC6583928
OpenAlexW2944815248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.