ArticleJMIR mental health2019
When All Else Fails, Listen to the Patient: A Viewpoint on the Use of Ecological Momentary Assessment in Clinical Trials.
Article in JMIR mental health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Synthesis of evidence on the use of ecological momentary assessments to monitor health outcomes after traumatic injury: rapid systematic review.BMC medical research methodology · 2022Pooled it
- Enhancing Assertive Community Treatment With Cognitive Behavioral Social Skills Training for Schizophrenia: II. Ecological Momentary Assessment Outcomes in a Pragmatic Randomized-Controlled Trial.Schizophrenia bulletin · 2026Trial
- High-Frequency, At-Home Monitoring of Drug Safety and Tolerability in Clinical Trials: Results From Studies of Fluvoxamine for COVID-19 Treatment.Clinical and translational science · 2025Trial
- Trial
- Comparing integrative cognitive-affective therapy and guided self-help cognitive-behavioral therapy to treat binge-eating disorder using standard and naturalistic momentary outcome measures: A randomized controlled trial.The International journal of eating disorders · 2020Trial
- Reducing Problematic Parenting Behaviors, Child Neglect, and Internalizing and Externalizing Problems in Multisystemic Therapy for Child Abuse and Neglect.Child maltreatment · 2026Article
- Exploring the use of smartphone monitoring for young adults with Tuberous Sclerosis Complex (TSC): a qualitative analysis.Orphanet journal of rare diseases · 2026Article
- Ecological Momentary Assessment as a Measure of Intervention Change: Evaluation in 4 Digital Mental Health Trials.Journal of medical Internet research · 2025Article
- Driven by rewards or punishments? Understanding real world social functioning in anxiety and depressive disorders.Journal of mood and anxiety disorders · 2025Article
- Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data.NPJ digital medicine · 2025Article
- Brain mechanisms of rumination and negative self-referential processing in adolescent depression.Journal of affective disorders · 2024Article
- Predicting Completion of Ecological Momentary Assessments Among Substance-Using Women Experiencing Intimate Partner Violence.Assessment · 2024Article
- Changing Knowledge, Principles, and Technology in Contemporary Clinical Audiological Practice: A Narrative Review.Journal of clinical medicine · 2024Review
- Digital and precision clinical trials: innovations for testing mental health medications, devices, and psychosocial treatments.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Feasibility of Using Research Electronic Data Capture (REDCap) to Collect Daily Experiences of Parent-Child Dyads: Ecological Momentary Assessment Study.JMIR formative research · 2023Article
- A smartphone- and wearable-based biomarker for the estimation of unipolar depression severity.Scientific reports · 2023Article
- The Modern Hearing Care Landscape: Toward the Provision of Personalized, Dynamic, and Adaptive Care.Seminars in hearing · 2023Review
- Delphi Consensus on Reporting Standards in Clinical Studies for Endovascular Treatment of Acute Iliofemoral Venous Thrombosis and Chronic Iliofemoral Venous Obstruction.Circulation. Cardiovascular interventions · 2023Review
- Venlafaxine XR treatment for older patients with major depressive disorder: decision trees for when to change treatment.Evidence-based mental health · 2022Article
- Mindfulness Training for Depressed Older Adults Using Smartphone Technology: Protocol for a Fully Remote Precision Clinical Trial.JMIR research protocols · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major problem in mental health clinical trials, such as depression, is low assay sensitivity in primary outcome measures. This has contributed to clinical trial failures, resulting in the exodus of the pharmaceutical industry from the Central Nervous System space. This reduced assay sensitivity in psychiatry outcome measures stems from inappropriately broad measures, recall bias, and poor interrater reliability. Limitations in the ability of traditional measures to differentiate between the trait versus state-like nature of individual depressive symptoms also contributes to measurement error in clinical trials. In this viewpoint, we argue that ecological momentary assessment (EMA)-frequent, real time, in-the-moment assessments of outcomes, delivered via smartphone-can both overcome these psychometric challenges and reduce clinical trial failures by increasing assay sensitivity and minimizing recall and rater bias. Used in this manner, EMA has the potential to further our understanding of treatment response by allowing for the assessment of dynamic interactions between treatment and distinct symptom response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.