ArticleAdvanced healthcare materials2019
Printing Therapeutic Proteins in 3D using Nanoengineered Bioink to Control and Direct Cell Migration.
Article in Advanced healthcare materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Next-Generation Biomaterials: Design Strategies, Clinical Translation, and the Rise of Intelligent Therapeutic Platforms.ACS omega · 2025Review
- 3D Bioprinting of Microbial-based Living Materials for Advanced Energy and Environmental Applications.Chem & bio engineering · 2024Review
- Biofabrication methods for reconstructing extracellular matrix mimetics.Bioactive materials · 2024Review
- Dynamically crosslinked thermoresponsive granular hydrogels.Journal of biomedical materials research. Part A · 2023Article
- Drug Delivery Systems in Regenerative Medicine: An Updated Review.Pharmaceutics · 2023Review
- Three-dimensional bioprinting of artificial blood vessel: Process, bioinks, and challenges.International journal of bioprinting · 2023Review
- Article
- Two-dimensional nanomaterials-added dynamism in 3D printing and bioprinting of biomedical platforms: Unique opportunities and challenges.Biomaterials · 2022Review
- Regenerating dynamic organs using biomimetic patches.Trends in biotechnology · 2022Review
- 2D layered nanomaterials for therapeutics delivery.Current opinion in biomedical engineering · 2021Article
- Emerging 2D Nanomaterials for Biomedical Applications.Materials today (Kidlington, England) · 2021Article
- The Importance of Interfaces in Multi-Material Biofabricated Tissue Structures.Advanced healthcare materials · 2021Review
- Clay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine.Pharmaceutics · 2021Review
- Regulation of cell locomotion by nanosecond-laser-induced hydroxyapatite patterning.Bioactive materials · 2021Article
- Biofabrication Strategies for Musculoskeletal Disorders: Evolution towards Clinical Applications.Bioengineering (Basel, Switzerland) · 2021Review
- Development of Nanosilicate-Hydrogel Composites for Sustained Delivery of Charged Biopharmaceutics.ACS applied materials & interfaces · 2021Article
- Two-dimensional metal organic frameworks for biomedical applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Development of Antibacterial Protective Coatings Active against MSSA and MRSA on Biodegradable Polymers.Polymers · 2021Article
- Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress.International journal of bioprinting · 2021Article
- Printability and Shape Fidelity of Bioinks in 3D Bioprinting.Chemical reviews · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
A nanoengineered bioink loaded with therapeutic proteins is designed to direct cell function in a 3D printed construct. The bioink is developed from a hydrolytically degradable polymer and 2D synthetic nanoparticle. The synthesis of poly(ethylene glycol)-dithiothreitol (PEGDTT) via a Michael-like step growth polymerization results in acrylate terminated degradable macromer. The addition of 2D nanosilicates to PEGDTT results in formation of shear-thinning bioinks with high printability and structural fidelity. The mechanical properties, swelling kinetics, and degradation rate of 3D printed constructs can be modulated by changing the ratio of PEG:PEGDTT and nanosilicates concentration. Due to high surface area and charged characteristic of nanosilicates, protein therapeutics can be sequestered in 3D printing structure for prolong duration. Sustained release of pro-angiogenic therapeutics from 3D printed structure, promoted rapid migration of human endothelial umbilical vein cell. This approach to design biologically active inks to control and direct cell behavior can be used to engineer 3D complex tissue structure for regenerative medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.