Evidence map›Paper›PMID 31066324›Full record

ArticleAutophagy2019

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.

Man J Livingston, Jinghong Wang, Jiliang Zhou, Guangyu Wu, Ian G Ganley, Joseph A Hill, Xiao-Ming Yin, Zheng Dong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 2 pooled it
18.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 2 syntheses or guidelines pooled it, 245 citations in OpenAlex.

  1. Pooled it
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  9. Mitophagy in kidney transplantation ischemia-reperfusion injury.International urology and nephrology · 2026
    Review
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  15. Autophagy · 2026
    Article
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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Man J LivingstonDepartment of Cellular Biology and Anatomy, Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, USA.
Jinghong WangDepartments of Laboratory Medicine and Nephrology The Second Xiangya Hospital, Central South University, Changsha, China.
Jiliang ZhouDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, USA.ORCID 0000-0002-2375-4636
Guangyu WuDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, USA.
Ian G GanleyMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, Scotland, UK.
Joseph A HillDivision of Cardiology, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiao-Ming YinDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Zheng DongDepartment of Cellular Biology and Anatomy, Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, USA.
Augusta University · USCentral South University · CNIndiana University School of MedicineThe University of Texas Southwestern Medical Center · USUniversity of Dundee · GB

Funding

Anterograde transport and signal regulation of GPCRsR01GM118915 · NIGMS · AUGUSTA UNIVERSITY · PI WU, GUANGYU · 2016 to 2019
$1.3M
Medical Research Council MC_UU_00018/2NIGMS NIH HHS R01 GM118915
6 · The paper itself

Abstract

Ischemic preconditioning (IPC) affords tissue protection in organs including kidneys; however, the underlying mechanism remains unclear. Here we demonstrate an important role of macroautophagy/autophagy (especially mitophagy) in the protective effect of IPC in kidneys. IPC induced autophagy in renal tubular cells in mice and suppressed subsequent renal ischemia-reperfusion injury (IRI). The protective effect of IPC was abolished by pharmacological inhibitors of autophagy and by the ablation of

Indexed as

Ischemic PreconditioningAnimalsApoptosisApoptosis Regulatory ProteinsAutophagosomesAutophagy-Related Protein 7Beclin-1Carbonyl Cyanide m-Chlorophenyl HydrazoneCell LineKidneyKidney Tubules, ProximalLysosomesMaleMiceMice, Inbred C57BLMice, TransgenicApoptosis Regulatory ProteinsAtg7 protein, mouseAutophagy-Related Protein 7Beclin-1Becn1 protein, mouseCarbonyl Cyanide m-Chlorophenyl HydrazoneProtein KinasesPTEN-Induced Putative KinaseReactive Oxygen SpeciesAcute kidney injuryautophagyischemic preconditioningmitophagyproximal tubulerenal ischemia-reperfusion

Identifiers

PMID31066324
PMCPMC6844514
OpenAlexW2944644737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.