Evidence map›Paper›PMID 31066227›Full record

SynthesisBrain and behavior2019

Transcranial magnetic stimulation in anxiety and trauma-related disorders: A systematic review and meta-analysis.

Patricia Cirillo, Alexandra K Gold, Antonio E Nardi, Ana C Ornelas, Andrew A Nierenberg, Joan Camprodon, Gustavo Kinrys

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03840369 (Pathophysiological Understanding and Treatment of PTSD), which is not on this map. Cited by 85 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 11 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03840369 nacompletednot on this mapstarted 2020, after this paper: background citation

Pathophysiological Understanding and Treatment of PTSD: an rTMS Approach

TypeinterventionalSponsorUniversity of CalgaryRan2020 to 2022Enrolled25ConditionsStress Disorders, Post-Traumatic, Brain Injuries, Transcranial Magnetic Stimulation, Magnetic Resonance SpectroscopyArmsRepetitive Transcranial Magnetic Stimulation to Right Dorsolateral Prefrontal Cortex, Sham Repetitive Transcranial Magnetic Stimulation, Repetitive Transcranial Magnetic Stimulation to Right Dorsomedial Prefrontal Cortex
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 11 syntheses or guidelines pooled it, 171 citations in OpenAlex.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Patricia CirilloDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Alexandra K GoldDepartment of Psychological and Brain Sciences, Boston University, Boston, Massachusetts.
Antonio E NardiUniversidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Ana C OrnelasUniversidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Andrew A NierenbergDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Joan CamprodonDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Gustavo KinrysDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0002-5845-8327
Universidade Federal do Rio de Janeiro · BRHarvard University · USBoston University · USMassachusetts General Hospital · US

Funding

A Transdiagnostic Assessment of Electroconvulsive Therapy Modulation of Anhedonia and Reward circuitry: Targets, Biomarkers and Predictors of ResponseR01MH112737 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A · 2017 to 2021
$3.8M
Neuromodulation of memory and language networks in Alzheimer's diseaseR21AG056958 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A, DICKERSON, BRADFORD C · 2017 to 2018
$467k
Modulating Inhibitory Control Networks In Gambling Disorder With Theta Burst StimulationR21DA042271 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A, MAKRIS, NIKOLAOS · 2017 to 2018
$439k
Impaired Risk Avoidance in Bipolar Disorder and Substance Use DisordersF31MH116557 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI GOLD, ALEXANDRA KATE · 2018 to 2021
$100k
NIA NIH HHS R21 AG056958NIDA NIH HHS R21 DA042271NIMH NIH HHS F31 MH116557NIMH NIH HHS R01 MH112737
6 · The paper itself

Abstract

backgroundTranscranial magnetic stimulation (TMS) has been evaluated as an effective treatment option for patients with major depressive disorder. However, there are limited studies that have evaluated the efficacy of TMS for other neuropsychiatric disorders such as anxiety and trauma-related disorders. We reviewed the literature that has evaluated TMS as a treatment for anxiety and trauma-related disorders.

methodsWe searched for articles published up to December 2017 in Embase, Medline, and ISI Web of Science databases, following the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses (PRISMA) statement. Articles (n = 520) evaluating TMS in anxiety and trauma-related disorders were screened and a small subset of these that met the eligibility criteria (n = 17) were included in the systematic review, of which nine evaluated TMS in posttraumatic stress disorder (PTSD), four in generalized anxiety disorder (GAD), two in specific phobia (SP), and two in panic disorder (PD). The meta-analysis was performed with PTSD and GAD since PD and SP had an insufficient number of studies and sample sizes.

resultsAmong anxiety and trauma-related disorders, TMS has been most widely studied as a treatment for PTSD. TMS demonstrated large overall treatment effect for both PTSD (ES = -0.88, 95% CI: -1.42, -0.34) and GAD (ES = -2.06, 95% CI: -2.64, -1.48), including applying high frequency over the right dorsolateral prefrontal cortex. Since few studies have evaluated TMS for SP and PD, few conclusions can be drawn.

conclusionsOur meta-analysis suggests that TMS may be an effective treatment for GAD and PTSD.

Indexed as

Anxiety DisordersHumansStress Disorders, Post-TraumaticTranscranial Magnetic StimulationTreatment Outcomeanxiety disordersmeta-analysisposttraumatic stress disordersystematic reviewtheta bursttranscranial magnetic stimulation

Identifiers

PMID31066227
PMCPMC6576151
OpenAlexW2944651682

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.