Evidence map›Paper›PMID 31065919›Full record

Trial reportObesity surgery2019

Bone Turnover Markers After Standard and Distal Roux-en-Y Gastric Bypass: Results from a Randomized Controlled Trial.

Marius Svanevik, Hilde Risstad, Dag Hofsø, Ingvild K Blom-Høgestøl, Jon A Kristinsson, Rune Sandbu, Milada Cvancarova Småstuen, Per Medbøe Thorsby, Tom Mala, Jøran Hjelmesæth

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00821197 (Long -Limb Gastric or Distal Gastric Bypass in the Treatment of Super Obese Patients - a Prospective Randomized Study), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00821197 naunknown statusnot on this map

Long -Limb Gastric or Distal Gastric Bypass in the Treatment of Super Obese Patients - a Prospective Randomized Study

TypeinterventionalSponsorOslo University HospitalRan2011 to 2025Enrolled115ConditionsObesityArmslong-limb gastric bypass, distal gastric bypass
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. The Short-Term Impact of Sleeve Gastrectomy on Bone Health.Mediterranean journal of rheumatology · 2025
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  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Marius SvanevikMorbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway. marius.svanevik@siv.no.ORCID 0000-0003-4303-5935
Hilde RisstadDepartment of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Dag HofsøMorbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway.
Ingvild K Blom-HøgestølDepartment of Endocrinology, Morbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Jon A KristinssonDepartment of Morbid Obesity and Bariatric Surgery, Oslo University Hospital, Oslo, Norway.
Rune SandbuMorbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway.
Milada Cvancarova SmåstuenMorbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway.
Per Medbøe ThorsbyHormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Tom MalaDepartment of Morbid Obesity and Bariatric Surgery, Oslo University Hospital, Oslo, Norway.
Jøran HjelmesæthMorbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway.
Oslo University Hospital · NOSykehuset i Vestfold · NOUniversity of Oslo · NOOsloMet – Oslo Metropolitan University · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRoux-en-Y gastric bypass is associated with increased risk of bone fractures. Malabsorptive procedures may be associated with secondary hyperparathyroidism and detrimental effects on bone health. We aimed to compare the effects of standard and distal gastric bypass on bone turnover markers 2 years after surgery.

methodsPatients with body mass index (BMI) 50-60 kg/m

resultsThe levels of bone turnover markers increased significantly in both groups, with no statistically significant difference between groups. Two years after standard and distal gastric bypass mean (SD) CTX-1 were 0.81 (0.32) and 0.83 (0.31) μg/L (p = 0.38), mean PINP was 77.6 (23.2) and 77.7 (29.3) μg/L (p = 0.42), and BALP 47.9 (21.9) vs. 50.7 (19.6) μg/L (p = 0.38), respectively. Multiple linear regression analyses showed that PINP and BALP correlated positively (p = 0.01 and p < 0.001) with PTH, but only BALP was significantly higher in patients with secondary hyperparathyroidism (p = 0.001). Type of surgery, vitamin D serum concentrations, and 2-year BMI were all independently associated with PTH levels.

conclusionA comparable increase in bone turnover markers 2 years after standard and distal gastric bypass was observed. There was a higher prevalence of secondary hyperparathyroidism after distal gastric bypass, but this did not impact bone turnover markers.

trial registrationClinical Trials.gov number NCT00821197.

Indexed as

Bone RemodelingAlkaline PhosphataseBiomarkersCollagen Type IGastric BypassHumansAlkaline PhosphataseBiomarkersCollagen Type IBariatric surgeryBoneGastric bypassMalabsorptive

Identifiers

PMID31065919
OpenAlexW2944300377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.