Evidence map›Paper›PMID 31065845›Full record

ArticleEuropean journal of nutrition2020

Mediterranean diet, physical activity and subcutaneous advanced glycation end-products' accumulation: a cross-sectional analysis in the ILERVAS project.

Enric Sánchez, Àngels Betriu, Jordi Salas-Salvadó, Reinald Pamplona, Ferrán Barbé, Francesc Purroy, Cristina Farràs, Elvira Fernández, Carolina López-Cano, Chadia Mizab and 2 more

Registry-linked trialAbstract read
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In one paragraph

Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03228459 (Randomized Intervention Study to Assess the Prevalence of Subclinical Vascular Disease and Hidden Kidney Disease and Its Impact on Morbidity and Mortality), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03228459 naactive not recruitingnot on this map

Randomized Intervention Study to Assess the Prevalence of Subclinical Vascular Disease and Hidden Kidney Disease and Its Impact on Morbidity and Mortality: The ILERVAS Project

TypeinterventionalSponsorInstitut de Recerca Biomèdica de LleidaRan2015 to 2028Enrolled16,660ConditionsAtherosclerosis, Chronic Kidney Diseases, Metabolic Syndrome, PreDiabetesArmsDried blood spot test, Urine test, Artery ultrasound, Ankle-brachial index, Spirometry
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Enric SánchezEndocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, Avda. Rovira Roure 80, 25198, Lleida, Catalonia, Spain.
Àngels BetriuUnit for the Detection and Treatment of Atherothrombotic Diseases (UDETMA V&R), University Hospital Arnau de Vilanova, Vascular and Renal Translational Research Group, IRBLleida, University of Lleida, Lleida, Catalonia, Spain.
Jordi Salas-SalvadóDepartment of Human Nutrition Unit, Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Hospital of Sant Joan de Reus, IISPV, Rovira i Virgili University, Reus, Spain.
Reinald PamplonaExperimental Medicine Department, IRBLleida, University of Lleida, Lleida, Catalonia, Spain.
Ferrán BarbéRespiratory Department, University Hospital Arnau de Vilanova-Santa María, Translational Research in Respiratory Medicine, IRBLleida, University of Lleida, Lleida, Catalonia, Spain.
Francesc PurroyStroke Unit, University Hospital Arnau de Vilanova, Clinical Neurosciences Group, IRBLleida, University of Lleida, Lleida, Catalonia, Spain.
Cristina FarràsPrimary Health Care Unit, Lleida, Catalonia, Spain.
Elvira FernándezUnit for the Detection and Treatment of Atherothrombotic Diseases (UDETMA V&R), University Hospital Arnau de Vilanova, Vascular and Renal Translational Research Group, IRBLleida, University of Lleida, Lleida, Catalonia, Spain.
Carolina López-CanoEndocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, Avda. Rovira Roure 80, 25198, Lleida, Catalonia, Spain.
Chadia MizabEndocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, Avda. Rovira Roure 80, 25198, Lleida, Catalonia, Spain.
Albert LecubeEndocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, Avda. Rovira Roure 80, 25198, Lleida, Catalonia, Spain. alecube@gmail.com.ORCID http://orcid.org/0000-0001-9684-0183
ILERVAS project investigators
Universitat de Lleida · ESInstituto de Salud Carlos III · ES

Funding

Generalitat de Catalunya 2017SGR696Generalitat de Catalunya SLT0021600250Instituto de Salud Carlos III Action Plan II14//00008
6 · The paper itself

Abstract

purposeAdherence to Mediterranean diet (MedDiet) and physical activity have been associated to lower cardiovascular risk and mortality. Our purpose was to test the modification of advanced glycation end-products (AGEs) as one of the underlying mechanisms explaining this relationship.

methodsCross-sectional study assessing the adherence to MedDiet (14-item Mediterranean Diet Adherence Screener) and physical activity (International Physical Activity Questionnaire short form) in 2646 middle-aged subjects without known cardiovascular disease and type 2 diabetes from the ILERVAS study. Skin autofluorescence (SAF), a non-invasive assessment of subcutaneous AGEs, was measured. Multivariable logistic regression models were done to study interactions and independent associations with a likelihood ratio test.

resultsParticipants with a high adherence to MedDiet had lower SAF than those with low adherence (1.8 [IR 1.6; 2.1] vs. 2.0 [IR 1.7; 2.3] arbitrary units, p < 0.001), without differences according to categories of physical activity. There was an independent association between high adherence to MedDiet and the SAF values [OR 0.59 (0.37-0.94), p = 0.026]. When adherence to MedDiet was substituted by its individual food components, high intake of vegetables, fruits and nuts, and low intake of sugar-sweetened soft beverages were independently associated with a decreased SAF (p ≤ 0.045). No interaction between MedDiet and physical activity on SAF values was observed except for nuts consumption (p = 0.047).

conclusionsAdherence to the MedDiet, but not physical activity, was negatively associated to SAF measurements. This association can be explained by some typical food components of the MedDiet. The present study offers a better understanding of the plausible biological conditions underlying the prevention of cardiovascular disease with MedDiet. ClinTrials.gov identifier: NCT03228459.

Indexed as

ExerciseCardiovascular DiseasesCross-Sectional StudiesDiet, MediterraneanFemaleGlycation End Products, AdvancedHumansMaleMiddle AgedOptical ImagingPatient ComplianceSkinGlycation End Products, AdvancedAdvanced glycation end-productsMediterranean dietPhysical activityQuestionnaireSkin autofluorescence

Identifiers

PMID31065845
OpenAlexW2943862655

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.