ArticleJournal of the Endocrine Society2019
Seventeen Cases of Primary Hyperparathyroidism in Pregnancy: A Call for Management Guidelines.
Article in Journal of the Endocrine Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Comparison between surgical and non-surgical management of primary hyperparathyroidism during pregnancy: a systematic review.Endocrine · 2024Pooled it
- Parathyroid adenoma in pregnancy: A case report and systematic review of the literature.Frontiers in endocrinology · 2022Pooled it
- Neonatal hypocalcemia caused by maternal hypercalcemia: clinical characteristics, etiology, treatment, and outcome.Pediatric research · 2026Article
- Gestational hypercalcemia: a narrative review of literature.Frontiers in medicine · 2026Review
- Disorders of bone and mineral metabolism in pregnancy and lactation: A case based clinical review.Osteoporosis and sarcopenia · 2025Review
- Gestational Ectopic Hyperparathyroidism: A Case Report of Perioperative and Perinatal Outcomes.Cureus · 2024Article
- Primary Hyperparathyroidism during Pregnancy: Two Tales with Different Outcomes.Journal of the ASEAN Federation of Endocrine Societies · 2024Article
- Case report: Microwave ablation is a safe and effective method for primary hyperparathyroidism in pregnancy.Frontiers in medicine · 2024Article
- Expert consensus on multidisciplinary approach to the diagnosis and treatment of primary hyperparathyroidism in pregnancy in China.Endocrine · 2023Article
- Approach to the Patient: Management of Parathyroid Diseases Across Pregnancy.The Journal of clinical endocrinology and metabolism · 2023Article
- Endocrinological cause behind recurrent miscarriages: primary hyperparathyroidism.Endocrinology, diabetes & metabolism case reports · 2023Article
- Primary hyperparathyroidism in pregnancy: experience of a tertiary centre.Surgery today · 2023Article
- A Fatal Case of Metastatic Pulmonary Calcification during the Puerperium.International journal of molecular sciences · 2022Article
- Review
- European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders.European journal of endocrinology · 2022Article
- Multidisciplinary team efforts to improve the pregnancy outcome of pregnancy complicated with primary hyperparathyroidism: case series from a single hospital.BMC pregnancy and childbirth · 2021Article
- Primary hyperparathyroidism in pregnancy: observations from the Indian PHPT registry.Journal of endocrinological investigation · 2021Observational
- Primary Hyperparathyroidism in Pregnancy: Literature Review of the Diagnosis and Management.Journal of clinical medicine · 2021Review
- Primary Hyperparathyroidism in Pregnancy: Insights From a Case of a 28-Year-Old Woman With Miscarriages and Hyperemesis Gravidarum.Annals of laboratory medicine · 2021Article
- Parathyroid Disease in Pregnancy and Lactation: A Narrative Review of the Literature.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe risks of primary hyperparathyroidism (pHPT) to pregnant women and their fetuses appear to increase commensurate with serum calcium levels. The management strategy for pHPT must be adapted in pregnancy and should reflect the severity of hypercalcemia. However, no guidelines exist to assist clinicians.
methodsThe experience of a high-volume multidisciplinary endocrine surgical service in treating a consecutive series of pregnant women with pHPT referred for parathyroidectomy is presented and data are compared with a nonpregnant cohort with pHPT. A review of pHPT and pregnancy outcomes in the literature is provided.
resultsSeventeen pregnant women and 247 age range-matched nonpregnant women with pHPT were referred for surgery over 11 years. Mean serum calcium level was higher in the pregnant cohort (2.89 vs 2.78 mmol/L;
conclusionpHPT in pregnancy is a threat to mother and child. Medical management may be appropriate in mild disease, but in moderate to severe disease, parathyroidectomy under general anesthesia in the second trimester is safe. Localization using ionizing radiation/MRI is unnecessary, because surgical intervention in a high-volume multidisciplinary setting has excellent outcomes. Guidelines on the topic would assist clinicians.
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Registered trials
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