ArticleJournal of dental anesthesia and pain medicine2019
Pain perception and efficacy of local analgesia using 2% lignocaine, buffered lignocaine, and 4% articaine in pediatric dental procedures.
Article in Journal of dental anesthesia and pain medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Can buccal infiltration of articaine replace traditional inferior alveolar nerve block for the treatment of mandibular molars in pediatric patients?: A systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2021Pooled it
- Trial
- Effectiveness of buffered local anesthetic solutions in pediatric nerve blocks and infiltration anesthesia: a systematic review and meta-analysis.Journal of dental anesthesia and pain medicine · 2026Review
- Role of Pharmacology in Dentistry: A Review of Analgesics, Antibiotics, and Local Anesthetics.Cureus · 2025Review
- Evaluating the pain at site, onset of action, duration and anesthetic efficacy of conventional, buffered lidocaine, and precooled lidocaine with intraoral cryotherapy application in patients with symptomatic irreversible pulpitis: A clinical study.Journal of conservative dentistry and endodontics · 2024Article
- Effect of cryoanesthesia and sweet tasting solution in reducing injection pain in pediatric patients aged 7-10 years: a randomized controlled trial.Journal of dental anesthesia and pain medicine · 2024Article
- Article
- A Comparative Evaluation of Pain Experience and Time of Onset of 2% Lignocaine and 4% Articaine in Inferior Alveolar Nerve Block among Pediatric Population: A Clinical Study.International journal of clinical pediatric dentistry · 2024Article
- Article
- Advances in pediatric dentistry: new approaches to pain control and anxiety reduction in children - a narrative review.Journal of dental anesthesia and pain medicine · 2023Review
- Sucrose solution for alleviating needle pain during inferior alveolar nerve block in children aged 7-10 years: a randomized clinical trial.Journal of dental anesthesia and pain medicine · 2023Article
- Anesthetic efficacy of buffered 4% articaine for mandibular first molar infiltration: a crossover clinical trial.Journal of dental anesthesia and pain medicine · 2023Article
- Comparison of the anesthetic effect of alkalized lidocaine versus non-alkalized lidocaine administered at a slow rate in mandibular primary molars.Journal of dental research, dental clinics, dental prospects · 2023Article
- Buffered articaine infiltration for primary maxillary molar extractions: a randomized controlled study.Journal of dental anesthesia and pain medicine · 2022Article
- Buffered versus unbuffered local anesthesia for inferior alveolar nerve block injections in children: a systematic review.Journal of dental anesthesia and pain medicine · 2020Review
- Effect of warming local anesthesia solutions before intraoral administration in dentistry: a systematic review.Journal of dental anesthesia and pain medicine · 2020Review
- Efficacy of Articaine vs Lignocaine for infiltration anaesthesia during primary molar extractions.Pakistan journal of medical sciencesReview
- Buffered versus Non-buffered Local Anaesthesia in Minor Oral Surgery - A Comparative Study.Annals of maxillofacial surgeryArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to compare the pain perception and anesthetic efficacy of 2% lignocaine with 1:200,000 epinephrine, buffered lignocaine, and 4% articaine with 1:200,000 epinephrine for the inferior alveolar nerve block.
methodsThis was a double-blind crossover study involving 48 children aged 5-10 years, who received three inferior alveolar nerve block injections in three appointments scheduled one week apart from the next. Pain on injection was assessed using the Wong-Baker Faces pain scale and the sound eye motor scale (SEM). Efficacy of anesthesia was assessed by subjective (tingling or numbness of the lip, tongue, and corner of mouth) and objective signs (pain on probing).
resultsPain perception on injection assessed with Wong-Baker scale was significantly different between buffered lignocaine and lignocaine (P < 0.001) and between buffered lignocaine and articaine (P = 0.041). The onset of anesthesia was lowest for buffered lignocaine, with a statistically significant difference between buffered lignocaine and lignocaine (P < 0.001). Moreover, the efficacy of local analgesia assessed using objective signs was significantly different between buffered lignocaine and lignocaine (P < 0.001) and between lignocaine and articaine.
conclusionBuffered lignocaine was the least painful and the most efficacious anesthetic agent during the inferior alveolar nerve block injection in 5-10-year-old patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.