ArticleAlzheimer's & dementia (New York, N. Y.)2019
Pregnancy loss and risk of later dementia: A nationwide cohort study, Denmark, 1977-2017.
Article in Alzheimer's & dementia (New York, N. Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Associations between adverse pregnancy outcomes and cognitive impairment and dementia: a systematic review and meta-analysis.The lancet. Healthy longevity · 2024Pooled it
- Women's midlife: the front line of Alzheimer prevention.The Journal of clinical investigation · 2026Review
- Vitamin D and calcium status in preeclampsia and pregnancy-induced hypertension.Biomolecules & biomedicine · 2025Observational
- Association of infertility and recurrent pregnancy loss with the risk of dementia.European journal of epidemiology · 2024Article
- Association between Female Reproductive Factors and Risk of Dementia.Journal of clinical medicine · 2024Review
- Ectopic pregnancy, its potential links to dementia risk and interactions with depression: insights from a nationwide cohort study.Frontiers in psychiatry · 2024Article
- Impact of adverse pregnancy outcomes on brain vascular health and cognition.Research and practice in thrombosis and haemostasis · 2024Article
- Pregnancy complications and later life women's health.Acta obstetricia et gynecologica Scandinavica · 2023Review
- Associations between parenthood and dementia in men and women: biology or confounding?BMC neurology · 2023Article
- Clinical value of mean platelet volume in predicting and diagnosing pre-eclampsia: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Reproductive factors and the risk of incident dementia: A cohort study of UK Biobank participants.PLoS medicine · 2022Article
- Adverse reproductive outcomes and future risk of incident dementia: The modifying effect of genetic susceptibility.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPregnancy losses may be associated with increased risks of dementia.
methodsWe conducted a register-based cohort study in 1,243,957 women with ≥1 pregnancy in Denmark in the period 1977-2015. Using Cox regression, we estimated hazard ratios (HRs) comparing risks of dementia in women with and without pregnancy losses.
resultsDuring 21,672,433 person-years of follow-up, 261,279 women experienced a pregnancy loss, and 2188 women were diagnosed with dementia. Stillbirth was associated with an 86% increased risk of dementia overall (HR 1.86, 95% confidence interval [CI] 1.28-2.71). By contrast, miscarriage was not associated with later risk of dementia overall (single miscarriage, HR 0.99, 95% CI 0.87-1.12; recurrent miscarriages, HR 1.06, 95% CI 0.84-1.35). Adjustment for cardiovascular disease, hypertension, and diabetes did not meaningfully alter the association magnitudes. DISCUSSION: Stillbirth and dementia may share underlying mechanisms, suggesting that a history of stillbirth should be considered when assessing dementia risk in women.
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