ReviewWorld journal of clinical pediatrics2019
Prevention of necrotizing enterocolitis in premature infants - an updated review.
Review in World journal of clinical pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- In-hospital mortality among neonates with necrotising enterocolitis in Ethiopia: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Evaluation of Risk and Preventive Factors for Necrotizing Enterocolitis in Premature Newborns. A Systematic Review of the Literature.Frontiers in pediatrics · 2022Pooled it
- Effects ofCell reports. Medicine · 2021Trial
- National Institutes of Health-Wide Workshop: Impact of Diet on Mucosal Immunity and Immune-Mediated Inflammatory Diseases of the Gastrointestinal Tract.Gastro hep advances · 2026Article
- Progressive microbial alterations in the human gut and lung across early life: implications for translational medicine.Frontiers in cellular and infection microbiology · 2026Review
- Photoacoustic imaging assessment of acute kidney injury associated with experimental necrotizing enterocolitis.bioRxiv : the preprint server for biology · 2025Article
- Short-term outcomes of oropharyngeal administration of colostrum in preterm neonates: a double-blind placebocontrolled randomized trial.Clinical and experimental pediatrics · 2025Article
- Photoacoustic imaging for non-invasive assessment of biomarkers of intestinal injury in experimental necrotizing enterocolitis.Pediatric research · 2025Article
- Pre- to Postbiotics: The Beneficial Roles of Pediatric Dysbiosis Associated with Inflammatory Bowel Diseases.Microorganisms · 2024Review
- Feeding Outcomes in Preterm Neonates with Antenatal Abnormal Umbilical Artery Doppler Profile: A Retrospective Cohort Study.Indian journal of pediatrics · 2024Article
- Necrotizing enterocolitis: current understanding of the prevention and management.Pediatric surgery international · 2024Review
- Restrictive Use of Empirical Antibiotics Is Associated with Improved Short Term Outcomes in Very Low Birth Weight Infants: A Single Center, Retrospective Cohort Study from China.Antibiotics (Basel, Switzerland) · 2023Article
- Clinical NEC prevention practices drive different microbiome profiles and functional responses in the preterm intestine.Nature communications · 2023Article
- Article
- Association of gastric residual volumes with necrotising enterocolitis in extremely preterm infants-a case-control study.European journal of pediatrics · 2022Article
- Battling Enteropathogenic Clostridia: Phage Therapy forFrontiers in microbiology · 2022Review
- Fetal-neonatal exposure to antibiotics and NEC development: A systematic review and meta-analysis.Frontiers in pediatrics · 2022Review
- Prospects for clinical applications of butyrate-producing bacteria.World journal of clinical pediatrics · 2021Review
- The effects of IGF-1 and erythropoietin on apoptosis and telomerase activity in necrotizing enterocolitis model.Pediatric research · 2021Article
- Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development.Biomolecules · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing enterocolitis (NEC) is among the most common and devastating diseases encountered in premature infants, yet the true etiology continues to be poorly understood despite decades of research. Recently, gut bacterial dysbiosis has been proposed as a risk factor for the development of NEC. Based on this theory, several best clinical practices designed to reduce the risk of NEC have been proposed and/or implemented. This review summarizes the results of recent clinical trials and meta-analyses that support some of the existing clinical practices for reducing the risk of NEC in premature infants. It is evident that human milk feeding can reduce the incidence of NEC. While most of the studies demonstrated that probiotic supplementation can significantly reduce the incidence of NEC in premature infants, there are still some concerns regarding the quality, safety, optimal dosage, and treatment duration of probiotic preparations. Antibiotic prophylaxis does not reduce the incidence of NEC, and prolonged initial empirical use of antibiotics might in fact increase the risk of NEC for high-risk premature infants. Lastly, standardized feeding protocols are strongly recommended, both for prevention of postnatal growth restriction and NEC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.