ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
Collagen Fibrils Mechanically Contribute to Tissue Contraction in an In Vitro Wound Healing Scenario.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 89 citations in OpenAlex.
- A flexible repertoire of wound closure strategies precedes whole-body regeneration.Nature communications · 2026Article
- Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores.Bioactive materials · 2026Article
- Biocompatible Ink Optimization Enables Functional Volumetric Bioprinting With Xolography.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Soft-Tissue Volume Augmentation at Dental Implant Placement Using Collagen-Based Matrix Characterized by Oriented Open Pore Structure: A Retrospective Study with a Median Follow-Up of 17 Months.Bioengineering (Basel, Switzerland) · 2025Article
- Increased substrate stiffness disrupts nuclear-cytoskeletal mechanical coupling in senescent cells.Materials today. Bio · 2025Article
- Mechanoadaptive polysaccharide conjugates architect pro-healing microenvironments via dynamic stress redistribution in skin defects.Science advances · 2025Article
- Advances in Preparation and Biomedical Applications of Sodium Alginate-Based Electrospun Nanofibers.Gels (Basel, Switzerland) · 2025Review
- Improved prebiotic-based "shield" equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota.Acta pharmaceutica Sinica. B · 2025Article
- Wound Healing Effects of New Cream Formulations with Herbal Ingredients.Pharmaceutics · 2025Article
- Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology.Nature biomedical engineering · 2025Article
- A pro-angiogenic wound dressing embedded with natural spider silk protein.Regenerative biomaterials · 2025Article
- Targeting persistently activated inflammatory microenvironment to promote chronic wound healing.Frontiers in immunology · 2025Review
- Network Pharmacology, Molecular Docking and Experimental Validation on Potential Application of Diabetic Wound Healing ofDrug design, development and therapy · 2025Article
- Focal adhesion-mediated directional cell migration guided by gradient-stretched substrate.iScience · 2024Article
- A two-way street - cellular metabolism and myofibroblast contraction.NPJ Regenerative medicine · 2024Review
- External Mechanical Stability Regulates Hematoma Vascularization in Bone Healing Rather than Endothelial YAP/TAZ Mechanotransduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Investigation of the cellular and molecular effects of dehydrozingerone formulation on various days of diabetic wound repair.3 Biotech · 2024Article
- Article
- A roadmap for developing and engineeringBiophysics reviews · 2023Review
- How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth.Science advances · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound contraction is an ancient survival mechanism of vertebrates that results from tensile forces supporting wound closure. So far, tissue tension was attributed to cellular forces produced by tissue-resident (myo-)fibroblasts alone. However, difficulties in explaining pathological deviations from a successful healing path motivate the exploration of additional modulatory factors. Here, it is shown in a biomaterial-based in vitro wound healing model that the storage of tensile forces in the extracellular matrix has a significant, so-far neglected contribution to macroscopic tissue tension. In situ monitoring of tissue forces together with second harmonic imaging reveal that the appearance of collagen fibrils correlates with tissue contraction, indicating a mechanical contribution of tensioned collagen fibrils in the contraction process. As the re-establishment of tissue tension is key to successful wound healing, the findings are expected to advance the understanding of tissue healing but also underlying principles of misregulation and impaired functionality in scars and tissue contractures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.