Evidence map›Paper›PMID 31065511›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019

CD146-Targeted Multimodal Image-Guided Photoimmunotherapy of Melanoma.

Weijun Wei, Dawei Jiang, Emily B Ehlerding, Todd E Barnhart, Yunan Yang, Jonathan W Engle, Quan-Yong Luo, Peng Huang, Weibo Cai

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
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  4. Review
  5. Article
  6. Review
  7. Claudin18.2-targeted cancer theranostics.American journal of nuclear medicine and molecular imaging · 2023
    Review
  8. Article
  9. Development and comparison ofMolecular therapy oncolytics · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. ImmunoPET imaging of multiple myeloma with [European journal of nuclear medicine and molecular imaging · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Weijun WeiDepartment of Nuclear Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital 600 Yishan Road Shanghai 200233 China.
Dawei JiangDepartment of Radiology University of Wisconsin-Madison Madison WI 53705 USA.
Emily B EhlerdingDepartment of Medical Physics University of Wisconsin-Madison Madison WI 53705 USA.
Todd E BarnhartDepartment of Medical Physics University of Wisconsin-Madison Madison WI 53705 USA.
Yunan YangDepartment of Radiology University of Wisconsin-Madison Madison WI 53705 USA.
Jonathan W EngleDepartment of Medical Physics University of Wisconsin-Madison Madison WI 53705 USA.
Quan-Yong LuoDepartment of Nuclear Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital 600 Yishan Road Shanghai 200233 China.
Peng HuangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Carson International Cancer Center Laboratory of Evolutionary Theranostics School of Biomedical Engineering Health Science Center Shenzhen University Shenzhen 518060 China.
Weibo CaiDepartment of Radiology University of Wisconsin-Madison Madison WI 53705 USA.ORCID https://orcid.org/0000-0003-4641-0833
University of Wisconsin–Madison · USShanghai Jiao Tong University · CNShenzhen University · CN

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Special BD LSR FortessaS10OD018202 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI PATANKAR, MANISH S · 2014 to 2014
$351k
NCI NIH HHS P30 CA014520NCI NIH HHS T32 CA009206NIGMS NIH HHS T32 GM008505NIH HHS S10 OD018202
6 · The paper itself

Abstract

For melanoma resistant to molecularly targeted therapy and immunotherapy, new treatment strategies are urgently needed. A molecularly targeted theranostic pair may thus be of importance, where the diagnostic probe facilitates patient stratification and the therapeutic companion treats the selected cases. For this purpose, flow cytometry is used to assess the CD146 level in melanoma cells. Based on YY146, a CD146-specific monoclonal antibody, an imaging probe

Indexed as

immunoPETmelanomaphotoimmunotherapytheranosticsYY146

Identifiers

PMID31065511
PMCPMC6498137
OpenAlexW2917458219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.