Evidence map›Paper›PMID 31065438›Full record

ArticleBiomedical optics express2018

Integrated RFA/PSOCT catheter for real-time guidance of cardiac radio-frequency ablation.

Xiaowei Zhao, Xiaoyong Fu, Colin Blumenthal, Yves T Wang, Michael W Jenkins, Christopher Snyder, Mauricio Arruda, Andrew M Rollins

Abstract read
In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  5. Article
  6. Automated analysis framework forBiomedical optics express · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Heterogeneity Measurement of Cardiac Tissues Leveraging Uncertainty Information from Image Segmentation.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2020
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Optical coherence tomography imaging of cardiac substrates.Quantitative imaging in medicine and surgery · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaowei ZhaoDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Xiaoyong FuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Colin BlumenthalSchool of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Yves T WangDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Michael W JenkinsDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Christopher SnyderDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA.
Mauricio ArrudaDepartment of Cardiology, University Hospitals Case Medical Center, Cleveland, OH 44120, USA.
Andrew M RollinsDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.

Funding

OCT Imaging Technology for Developmental Cardiology ResearchR01HL083048 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ROLLINS, ANDREW MARTIN · 2006 to 2016
$3.2M
Staging of upper tract urothelial cancer with optical coherence tomographyR21CA165398 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI ROLLINS, ANDREW MARTIN, ZHU, HUI · 2012 to 2013
$549k
Cardiac radiofrequency ablation catheter with integrated OCT imagingR21HL129147 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ROLLINS, ANDREW MARTIN · 2015 to 2016
$436k
Rap1a mediates ECM remodeling by intersecting AGE/RAGE signaling in type II diabetes mellitusR15HL129174 · NHLBI · MISSISSIPPI STATE UNIVERSITY · PI STEWART, JAMES ALFRED · 2016 to 2016
$64k
NCI NIH HHS R21 CA165398NHLBI NIH HHS R01 HL083048NHLBI NIH HHS R15 HL129174NHLBI NIH HHS R21 HL129147
6 · The paper itself

Abstract

Radiofrequency ablation (RFA) is an important standard therapy for cardiac arrhythmias, but direct monitoring of tissue treatment is currently lacking. We demonstrate an RFA catheter integrated with polarization sensitive optical coherence tomography (PSOCT) for directly monitoring the RFA process in real time. The integrated RFA/OCT catheter was modified from a standard clinical RFA catheter and includes a miniature forward-viewing cone-scanning OCT probe. The PSOCT system was validated with a quarter-wave plate while the RFA function of the integrated catheter was validated by comparing lesion sizes with those made with an unmodified RFA catheter. Additionally, the integrated catheter guided catheter-tissue apposition and monitored RFA lesion formation in cardiac tissue in real time. The results show that catheter-tissue contact can be characterized by observing the features of the blood and tissue in the acquired OCT images and that RFA lesion formation can be confirmed by monitoring the change in phase retardance in the acquired PSOCT images. This system demonstrates the feasibility of an integrated RFA/OCT catheter to deliver RF energy and image the cardiac wall simultaneously and justifies further research into use of this technology to aid RFA therapy for cardiac arrhythmias.

Indexed as

(110.4500) Optical coherence tomography(170.2150) Endoscopic imaging(170.3890) Medical optics instrumentation

Identifiers

PMID31065438
PMCPMC6490984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.