ArticleBiomedical optics express2018
High resolution combined molecular and structural optical imaging of colorectal cancer in a xenograft mouse model.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Theranostics in the management of colorectal cancer.Discover nano · 2025Review
- Multimodal Optical Imaging of Ex Vivo Fallopian Tubes to Distinguish Early and Occult Tubo-Ovarian Cancers.Cancers · 2024Article
- Ex vivo optical coherence tomography combined with near infrared targeted fluorescence: towardsBiomedical optics express · 2024Article
- All-reflective tethered capsule endoscope for multimodal optical coherence tomography in the esophagus.Journal of biomedical optics · 2024Article
- Double-Clad Fiber-Based Multifunctional Biosensors and Multimodal Bioimaging Systems: Technology and Applications.Biosensors · 2022Review
- Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer.Frontiers in oncology · 2022Review
- MEX3A knockdown inhibits the tumorigenesis of colorectal cancer via modulating CDK2 expression.Experimental and therapeutic medicine · 2021Article
- TOPKi-NBD: a fluorescent small molecule for tumor imaging.European journal of nuclear medicine and molecular imaging · 2020Article
- Coregistered optical coherence tomography and frequency-encoded multispectral imaging for spectrally sparse color imaging.Journal of biomedical optics · 2019Article
- Article
- Revealing brain pathologies with multimodal visible light optical coherence microscopy and fluorescence imaging.Journal of biomedical optics · 2019Article
- Calibration of fluorescence imaging for tumor surgical margin delineation: multistep registration of fluorescence and histological images.Journal of medical imaging (Bellingham, Wash.) · 2019Article
- Advances in Optical Coherence Tomography and Confocal Laser Endomicroscopy in Pulmonary Diseases.Respiration; international review of thoracic diseasesReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the emergence of immunotherapies for cancer treatment, there is a rising clinical need to visualize the tumor microenvironment (TME) non-invasively in detail, which could be crucial to predict the efficacy of therapy. Nuclear imaging techniques enable whole-body imaging but lack the required spatial resolution. Conversely, near-infrared immunofluorescence (immuno-NIRF) is able to reveal tumor cells and/or other cell subsets in the TME by targeting the expression of a specific membrane receptor with fluorescently labeled monoclonal antibodies (mAb). Optical coherence tomography (OCT) provides three-dimensional morphological imaging of tissues without exogenous contrast agents. The combination of the two allows molecular and structural contrast at a resolution of ~15 µm, allowing for the specific location of a cell-type target with immuno-NIRF as well as revealing the three-dimensional architectural context with OCT. For the first time, combined immuno-NIRF and OCT of a tumor is demonstrated
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.