ArticleBiomedical optics express2018
All-optical imaging and manipulation of whole-brain neuronal activities in behaving larval zebrafish.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Article
- Functional interrogation of neuronal connections by chemoptogenetic presynaptic ablation.Science advances · 2026Article
- Two-photon all-optical neurophysiology for the dissection of larval zebrafish brain functional and effective connectivity.Communications biology · 2024Article
- Axial de-scanning using remote focusing in the detection arm of light-sheet microscopy.Nature communications · 2024Article
- Advancing neuroscience through real-time processing of big data: Transition from open-loop to closed-loop paradigms.Zoological research · 2024Article
- Removing crosstalk signals in neuron activity by time multiplexed excitations in a two-photon all-optical physiology system.Biomedical optics express · 2024Article
- All-optical interrogation of brain-wide activity in freely swimming larval zebrafish.iScience · 2024Article
- Calcium Imaging Characterize the Neurobiological Effect of Terahertz Radiation in Zebrafish Larvae.Sensors (Basel, Switzerland) · 2023Article
- Review
- Platforms for Optogenetic Stimulation and Feedback Control.Frontiers in bioengineering and biotechnology · 2022Review
- PyZebrascope: An Open-Source Platform for Brain-Wide Neural Activity Imaging in Zebrafish.Frontiers in cell and developmental biology · 2022Article
- Learning-dependent neuronal activity across the larval zebrafish brain.Current opinion in neurobiology · 2021Review
- Anatomy and activity patterns in a multifunctional motor neuron and its surrounding circuits.eLife · 2021Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All-optical interrogation of population neuron activity is a promising approach to deciphering the neural circuit mechanisms supporting brain functions. However, this interrogation is currently limited to local brain areas. Here, we incorporate patterned photo-stimulation into light-sheet microscopy, allowing simultaneous targeted optogenetic manipulation and brain-wide monitoring of the neuronal activities of head-restrained behaving larval zebrafish. Using this system, we photo-stimulate arbitrarily selected neurons (regions as small as ~10-20 neurons in 3D) in zebrafish larvae with pan-neuronal expression of a spectrally separated calcium indicator, GCaMP6f, and an activity actuator, ChrimsonR, and observe downstream neural circuit activation and behavior generation. This approach allows us to dissect the causal role of neural circuits in brain functions and behavior generation.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.