ArticleBiomedical optics express2018
Quantitative real-time pulse oximetry with ultrafast frequency-domain diffuse optics and deep neural network processing.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Ninety years of pulse oximetry: history, current status, and outlook.Journal of biomedical optics · 2024Review
- Tutorial on methods for estimation of optical absorption and scattering properties of tissue.Journal of biomedical optics · 2024Article
- Compressed single-shot 3D photoacoustic imaging with a single-element transducer.Photoacoustics · 2023Article
- Shortwave infrared diffuse optical wearable probe for quantification of water and lipid content in emulsion phantoms using deep learning.Journal of biomedical optics · 2023Article
- Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited].Biomedical optics express · 2023Review
- Single-shot photoacoustic imaging with single-element transducer through a spatiotemporal encoder.Journal of biomedical optics · 2023Article
- A scalable, multi-wavelength, broad bandwidth frequency-domain near-infrared spectroscopy platform for real-time quantitative tissue optical imaging.Biomedical optics express · 2021Article
- Real-Time Handheld Probe Tracking and Image Formation Using Digital Frequency-Domain Diffuse Optical Spectroscopy.IEEE transactions on bio-medical engineering · 2021Article
- Imaging sub-diffuse optical properties of cancerous and normal skin tissue using machine learning-aided spatial frequency domain imaging.Journal of biomedical optics · 2021Article
- The Challenges and Pitfalls of Detecting Sleep Hypopnea Using a Wearable Optical Sensor: Comparative Study.Journal of medical Internet research · 2021Article
- Hemodynamics of the sternocleidomastoid measured with frequency domain near-infrared spectroscopy towards non-invasive monitoring during mechanical ventilation.Biomedical optics express · 2021Article
- Modulation frequency selection and efficient look-up table inversion for frequency domain diffuse optical spectroscopy.Journal of biomedical optics · 2021Article
- Direct mapping from diffuse reflectance to chromophore concentrations in multi-Biomedical optics express · 2021Article
- Frequency-Domain Techniques for Cerebral and Functional Near-Infrared Spectroscopy.Frontiers in neuroscience · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulse oximetry is a ubiquitous optical technology, widely used for diagnosis and treatment guidance. Current pulse oximeters provide indications of arterial oxygen saturation. We present here a new quantitative methodology that extends the capability of pulse oximetry and provides real-time molar concentrations of oxy- and deoxy-hemoglobin at rates of up to 27 Hz by using advanced digital hardware, real-time firmware processing, and ultra-fast optical property calculations with a deep neural network (DNN). The technique utilizes a high-speed frequency domain spectroscopy system with five frequency-multiplexed wavelengths. High-speed demultiplexing and data reduction were performed in firmware. The DNN inversion algorithm was benchmarked as five orders of magnitude faster than conventional iterative methods for optical property extractions. The DNN provided unbiased optical property extractions, with an average error of 0 ± 5.6% in absorption and 0 ± 1.4% in reduced scattering. Together, these improvements enabled the measurement, calculation, and real-time continuous display of hemoglobin concentrations. A proof-of-concept cuff occlusion measurement was performed to demonstrate the ability of the device to track oxy- and deoxy-hemoglobin, and measure quantitative photoplethysmographic changes during the cardiac cycle. This technique substantially extends the capability of pulse oximetry and provides unprecedented real-time non-invasive functional information with broad applicability for cardiopulmonary applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.