Evidence map›Paper›PMID 31065374›Full record

ArticleUnited European gastroenterology journal2019

The treatment of achalasia patients with esophageal varices: an international study.

M Pesce, C Magee, R H Holloway, C P Gyawali, S Roman, M Pioche, E Savarino, F Quader, G Sarnelli, S Sanagapalli and 2 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in United European gastroenterology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Peroral endoscopic myotomy in the presence of small esophageal varices.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024
    Article
  4. Article
  5. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

M PesceDepartment of Gastroenterology, Department of GI Physiology, University College London Hospitals, London, UK.
C MageeDepartment of Gastroenterology, Department of GI Physiology, University College London Hospitals, London, UK.
R H HollowayRoyal Adelaide Hospital, Adelaide, Australia.
C P GyawaliDivision of Gastroenterology, Washington University, St Louis, MO, USA.ORCID 0000-0002-3388-0660
S RomanDepartment of Gastroenterology, Digestive Physiology, Hospices Civils de Lyon and Lyon University, Lyon, France.
M PiocheDepartment of Gastroenterology, Digestive Physiology, Hospices Civils de Lyon and Lyon University, Lyon, France.
E SavarinoUniversity of Padova, Padova, Italy.
F QuaderDivision of Gastroenterology, Washington University, St Louis, MO, USA.
G SarnelliUniversity of Naples "Federico II", Naples, Italy.ORCID 0000-0002-1467-1134
S SanagapalliDepartment of Gastroenterology, Department of GI Physiology, University College London Hospitals, London, UK.
A J BredenoordDivision of Gastroenterology and Hepatology, Amsterdam Medical Centre, Amsterdam, Netherlands.
R SweisDepartment of Gastroenterology, Department of GI Physiology, University College London Hospitals, London, UK.
Royal London Hospital · GBUniversité Claude Bernard Lyon 1 · FRWashington University in St. Louis · USRoyal Adelaide Hospital · AUUniversity of Naples Federico II · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Treatment options for achalasia include endoscopic and surgical techniques that carry the risk of esophageal bleeding and perforation. The rare coexistence of esophageal varices has only been anecdotally described and treatment is presumed to carry additional risk. Methods: Experience from physicians/surgeons treating this rare combination of disorders was sought through the International Manometry Working Group. Results: Fourteen patients with achalasia and varices from seven international centers were collected (mean age 61 ± 9 years). Five patients were treated with botulinum toxin injections (BTI), four had dilation, three received peroral endoscopic myotomy (POEM), one had POEM then dilation, and one patient underwent BTI followed by Heller's myotomy. Variceal eradication preceded achalasia treatment in three patients. All patients experienced a significant symptomatic improvement (median Eckardt score 7 vs 1; Conclusion: This study shows an excellent short-term symptomatic response in patients with esophageal achalasia and varices and demonstrates that the therapeutic outcomes and complications, other than transient encephalopathy in both patients who had a portosystemic shunt, did not differ to disease-matched patients without varices.

Indexed as

AgedBotulinum ToxinsDilatationEsophageal AchalasiaEsophageal and Gastric VaricesEsophageal Sphincter, LowerEsophagoscopyFemaleFollow-Up StudiesHeller MyotomyHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeBotulinum Toxinsachalasia treatmentbotulinum toxin injectionEsophageal varicesperoral endoscopic myotomypneumatic dilation

Identifiers

PMID31065374
PMCPMC6488800
OpenAlexW2931718567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.