Evidence map›Paper›PMID 31065370›Full record

Observational studyUnited European gastroenterology journal2019

Terlipressin and albumin combination treatment in patients with hepatorenal syndrome type 2.

Marc Nguyen-Tat, Julia Jäger, Johannes Wilhelm Rey, Michael Nagel, Christian Labenz, Marcus-Alexander Wörns, Peter Robert Galle, Jens Uwe Marquardt

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in United European gastroenterology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marc Nguyen-TatFirst Department of Medicine, Cirrhosis Center Mainz (CCM), University Hospital Mainz, Mainz, Germany.ORCID 0000-0003-1809-9072
Julia JägerFirst Department of Medicine, Cirrhosis Center Mainz (CCM), University Hospital Mainz, Mainz, Germany.
Johannes Wilhelm ReyDepartment of Medicine II, Klinikum Osnabrück, Osnabrück, Germany.
Michael NagelFirst Department of Medicine, Cirrhosis Center Mainz (CCM), University Hospital Mainz, Mainz, Germany.
Christian LabenzFirst Department of Medicine, Cirrhosis Center Mainz (CCM), University Hospital Mainz, Mainz, Germany.
Marcus-Alexander WörnsFirst Department of Medicine, Cirrhosis Center Mainz (CCM), University Hospital Mainz, Mainz, Germany.
Peter Robert GalleFirst Department of Medicine, Cirrhosis Center Mainz (CCM), University Hospital Mainz, Mainz, Germany.
Jens Uwe MarquardtFirst Department of Medicine, Cirrhosis Center Mainz (CCM), University Hospital Mainz, Mainz, Germany.
Johannes Gutenberg University Mainz · DEKlinikum Osnabrück · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatorenal syndrome (HRS) is associated with a poor prognosis. In HRS type 1, loss of renal function is rapidly progressive, while HRS type 2 is characterised by chronic ascites and more moderately elevated renal parameters. While treatment with terlipressin/albumin is well established in type 1, its effectiveness in chronic HRS is less clear. Objective: The aim of this study was to evaluate the effectiveness of terlipressin/albumin treatment in patients with HRS type 2. Methods: All patients with a first episode of HRS between April 2013 and February 2016 were included in this observational study. Relevant clinical and laboratory parameters were recorded and patients were followed. Results: A total of 106 patients with HRS were included. With terlipressin therapy reversal of HRS types 1 and 2 was achieved in 48% and 46% of patients ( Conclusion: A terlipressin treatment course seems to be justified in selected patients with HRS type 2, especially in countries and settings with long transplant waiting lists. In addition treatment response might also help to identify HRS type 2 patients with a more favourable outcome.

Indexed as

AgedAlbuminsDrug Therapy, CombinationFemaleFollow-Up StudiesHepatorenal SyndromeHumansKaplan-Meier EstimateLiver CirrhosisLiver TransplantationMaleMiddle AgedRecurrenceRemission InductionTerlipressinTreatment OutcomeAlbuminsTerlipressinVasoconstrictor AgentsAKIalbuminhepatorenal syndromeHRSliver cirrhosisterlipressin

Identifiers

PMID31065370
PMCPMC6488797
OpenAlexW2915993845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.