Evidence map›Paper›PMID 31065021›Full record

ArticleScientific reports2019

VEGF Receptor 1-Expressing Macrophages Recruited from Bone Marrow Enhances Angiogenesis in Endometrial Tissues.

Kazuki Sekiguchi, Yoshiya Ito, Kyoko Hattori, Tomoyoshi Inoue, Kanako Hosono, Masako Honda, Akiko Numao, Hideki Amano, Masabumi Shibuya, Nobuya Unno and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Angiogenic Doping: Plausible Yet Difficult to Detect.Sports medicine (Auckland, N.Z.) · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Lenvatinib enhances antitumor immunity of anti-PD-1 antibody.International journal of clinical oncology · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kazuki SekiguchiDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Yoshiya ItoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Kyoko HattoriDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Tomoyoshi InoueDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Kanako HosonoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Masako HondaDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Akiko NumaoDepartment of Obstetrics and Gynecology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Hideki AmanoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Masabumi ShibuyaGakubunkan Institute of Physiology and Medicine, Jobu University, Takasaki, Gunma, Japan.
Nobuya UnnoDepartment of Obstetrics and Gynecology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Masataka MajimaDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. mmajima@med.kitasato-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiogenesis is critical in maintenance of endometrial tissues. Here, we examined the role of VEGF receptor 1 (VEGFR1) signaling in angiogenesis and tissue growth in an endometriosis model. Endometrial fragments were implanted into the peritoneal wall of mice, and endometrial tissue growth and microvessel density (MVD) were determined. Endometrial fragments from wild-type (WT) mice grew slowly with increased angiogenesis determined by CD31

Indexed as

AnimalsBone Marrow CellsCD11b AntigenEndometriosisEndometriumFemaleMacrophagesMice, Inbred C57BLMice, TransgenicMicrovesselsNeovascularization, PhysiologicProtein Kinase InhibitorsPyrimidinesVascular Endothelial Growth Factor Receptor-1CD11b AntigenPD 173074Protein Kinase InhibitorsPyrimidinesVascular Endothelial Growth Factor Receptor-1

Identifiers

PMID31065021
PMCPMC6504918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.