Evidence map›Paper›PMID 31065018›Full record

SynthesisScientific reports2019

The efficiency and safety of steroid addition to multimodal cocktail periarticular injection in knee joint arthroplasty: a meta-analysis of randomized controlled trials.

Zhenhan Deng, Yusheng Li, Garrett R Storm, Ronak Naveenchandra Kotian, Xuying Sun, Guanghua Lei, Shanshan Gao, Wei Lu

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05113901 (Methylprednisolone Taper to Treat Delayed Post-Operative Recovery After Total Knee Arthroplasty), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05113901 phase4terminatednot on this mapstarted 2022, after this paper: background citation

Methylprednisolone Taper to Treat Delayed Post-Operative Recovery After Total Knee Arthroplasty: a Double-Blind Randomized Controlled Trial

TypeinterventionalSponsorRush University Medical CenterRan2022 to 2022Enrolled4ConditionsTotal Knee ArthroplastyArmsMethylprednisolone, Placebo
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Expert consensus on glucocorticoids injection for knee osteoarthritis.Journal of orthopaedic surgery and research · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Pain Management of Hallux Valgus Surgery Is Achieved by Cocktail Therapy.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Zhenhan DengDepartment of Sports Medicine, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Yusheng LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China. liyusheng@csu.edu.cn.
Garrett R StormDepartment of Cardiology, University of Colorado Denver, Aurora, Colorado, USA.
Ronak Naveenchandra KotianDepartment of Orthopaedics, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore, India.
Xuying SunDepartment of Orthopaedics, Biological Engineering and Regenerative Medicine Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Guanghua LeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shanshan GaoDepartment of Cardiology, University of Colorado Denver, Aurora, Colorado, USA. Shanshan.gao@ucdenver.edu.
Wei LuDepartment of Sports Medicine, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China. weilu9309@gmail.com.
University of Colorado Denver · USXiangya Hospital Central South University · CNCentral South University · CNShenzhen Second People's Hospital · CNTongji Hospital · CNVictoria Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Steroids are frequently used for postoperative pain relief without definite evidence. This study was conducted to assess the pain management effect of the addition of steroids to a multimodal cocktail periarticular injection (MCPI) in patients undergoing knee arthroplasty and evaluate their safety. Pubmed, Embase, and Cochrane Library were searched through April, 2018. A total of 918 patients from ten randomized controlled trials (RCTs) were ultimately included. Compared with placebo groups, steroids application could effectively relieve pain on postoperative day (POD)1; decrease C-Reactive protein (CRP) level on POD3; improve range of motion (ROM) in postoperative 5 days; reduce morphine consumption, achieve earlier straight leg raising (SLR), and shorten the length of stay (LOS) in hospital. With regards to adverse effects, it did not increase the risk of postoperative infection, postoperative nausea and vomiting (PONV), or other complications. However, no significant difference in pain relief, ROM, or increased Knee Society Knee Function Scores were found during long-term follow up. Overall, this meta-analysis ensured the efficiency and safety of steroids with MCPI in knee arthroplasty patients during the early postoperative period.

Indexed as

Arthroplasty, Replacement, KneeC-Reactive ProteinHumansInjections, Intra-ArticularLength of StayMorphinePostoperative Nausea and VomitingPostoperative PainRandomized Controlled Trials as TopicRange of Motion, ArticularSteroidsC-Reactive ProteinMorphineSteroids

Identifiers

PMID31065018
PMCPMC6505038
OpenAlexW2944311560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.