Evidence map›Paper›PMID 31064885›Full record

ArticleScience signaling2019

An intramembrane sensory circuit monitors sortase A-mediated processing of streptococcal adhesins.

Jeffrey W Hall, Bruno P Lima, Gaetan G Herbomel, Tata Gopinath, LeAnna McDonald, Michael T Shyne, John K Lee, Jens Kreth, Karen F Ross, Gianluigi Veglia and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  13. Article
  14. Role of SrtA in Pathogenicity ofMicroorganisms · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Jeffrey W HallDepartment of Biological and Diagnostic Sciences, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-0214-4062
Bruno P LimaDepartment of Biological and Diagnostic Sciences, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-4619-4712
Gaetan G HerbomelSection of Biological Chemistry, NIDCR-NIH, Bethesda, MD 20814, USA.
Tata GopinathDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
LeAnna McDonaldDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Michael T ShyneBiostatistical Design and Analysis Center (BDAC), Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2136-7392
John K LeeDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Jens KrethDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, OR 97239, USA.ORCID 0000-0002-8599-8310
Karen F RossDepartment of Biological and Diagnostic Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
Gianluigi VegliaDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2795-6964
Mark C HerzbergDepartment of Biological and Diagnostic Sciences, University of Minnesota, Minneapolis, MN 55455, USA. mcherzb@umn.edu.ORCID 0000-0002-1195-1704
University of Minnesota · USNational Institutes of Health · USOregon Health & Science University · USSouthern California Clinical and Translational Science Institute · US

Funding

NMR Structural Analysis of Calcium Regulation in MuscleR01GM064742 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VEGLIA, GIANLUIGI · 2002 to 2019
$7.1M
Minnesota Craniofacial Research Training ProgramT90DE022732 · NIDCR · UNIVERSITY OF MINNESOTA · PI MANSKY, KIM CARPENTER · 2012 to 2023
$4.9M
Regulation of Surface Protein Presentation on Streptococcus gordoniiR01DE025618 · NIDCR · UNIVERSITY OF MINNESOTA · PI HERZBERG, MARK C · 2016 to 2020
$2.2M
Investigating the role of lipoteichoic acid in surface protein presentationK08DE027705 · NIDCR · UNIVERSITY OF MINNESOTA · PI LIMA, BRUNO P · 2018 to 2022
$620k
Peptide signaling of adhesins in oral streptococci.F32DE025782 · NIDCR · UNIVERSITY OF MINNESOTA · PI HALL, JEFFREY WILLIAM · 2016 to 2017
$50k
NIDCR NIH HHS F32 DE025782NIDCR NIH HHS K08 DE027705NIDCR NIH HHS R01 DE025618NIDCR NIH HHS T90 DE022732NIGMS NIH HHS R01 GM064742
6 · The paper itself

Abstract

Bacterial adhesins mediate adhesion to substrates and biofilm formation. Adhesins of the LPXTG family are posttranslationally processed by the cell membrane-localized peptidase sortase A, which cleaves the LPXTG motif. This generates a short C-terminal peptide (C-pep) that remains in the cell membrane, whereas the mature adhesin is incorporated into the cell wall. Genes encoding adhesins of the oral bacterium

Indexed as

Adhesins, BacterialAmino Acid MotifsAmino Acid SequenceAminoacyltransferasesBacterial ProteinsBiofilmsCysteine EndopeptidasesDental PlaqueGene Expression Regulation, BacterialMembrane GlycoproteinsMutationPeptide FragmentsSalivaSequence Homology, Amino AcidStreptococcus gordoniiAdhesins, BacterialAminoacyltransferasesBacterial ProteinsCysteine EndopeptidasesMembrane GlycoproteinsPeptide Fragmentssortase A

Identifiers

PMID31064885
PMCPMC6662179
OpenAlexW2944092701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.