ArticleScience signaling2019
Polycystin 2 regulates mitochondrial Ca
Open access · greenAbstract read
In one paragraph
Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 93 citations in OpenAlex.
- RhoA through its various effectors mediate mitochondrial fragmentation in polycystic kidney disease.iScience · 2026Article
- Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review).International journal of molecular medicine · 2026Review
- The Role of Mitochondria in Polycystic Kidney Disease.International journal of molecular sciences · 2026Review
- The spatiotemporal dynamics of MAMs: mechanisms, pathologies, and therapeutic rewiring.Cellular & molecular biology letters · 2026Review
- Emerging roles of the ciliary-mitochondrial axis in cellular homeostasis and neuroprotection.Molecular neurodegeneration advances · 2025Article
- Update on the correlation between mitochondrial function and osteonecrosis of the femoral head osteocytes.Redox report : communications in free radical research · 2025Review
- Endoplasmic reticulum-mediated organelle crosstalk in kidney disease.Nature reviews. Nephrology · 2025Review
- Article
- Physiologic mechanisms underlying polycystic kidney disease.Physiological reviews · 2025Review
- The roles of mitochondria in global and local intracellular calcium signalling.Nature reviews. Molecular cell biology · 2025Review
- Review
- The Influence of Non-Pharmacological and Pharmacological Interventions on the Course of Autosomal Dominant Polycystic Kidney Disease.Nutrients · 2024Review
- β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease.iScience · 2024Article
- Calcium signalling and transport in the kidney.Nature reviews. Nephrology · 2024Review
- Reprogramming of Energy Metabolism in HumanInternational journal of molecular sciences · 2024Article
- Cardiovascular perspectives of the TRP channel polycystin 2.The Journal of physiology · 2024Article
- Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis.Nature communications · 2023Article
- From Physiology to Pathology: The Role of Mitochondria in Acute Kidney Injuries and Chronic Kidney Diseases.Kidney diseases (Basel, Switzerland) · 2023Review
- Calcium signaling in polycystic kidney disease- cell death and survival.Cell calcium · 2023Review
- Polycystin Channel Complexes.Annual review of physiology · 2023Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Ivana Y KuoDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA. barbara.ehrlich@yale.edu ikuo@luc.edu.ORCID 0000-0002-9867-2408
Allison L BrillDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-5046-3578
Fernanda O LemosDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA.
Jason Y JiangDepartment of Surgery, Harvard Medical School, Brigham and Women's Hospital, MA 02132, USA.ORCID 0000-0001-8376-0619
Jeffrey L FalconeDepartment of Surgery, Harvard Medical School, Brigham and Women's Hospital, MA 02132, USA.ORCID 0000-0003-0429-0597
Erica P KimmerlingDepartment of Biomedical Engineering, Tufts University. Medford, MA 02155, USA.
Yiqiang CaiDepartment of Internal Medicine, Yale University School of Medicine. New Haven, CT 06510, USA.
Ke DongDepartment of Internal Medicine, Yale University School of Medicine. New Haven, CT 06510, USA.ORCID 0000-0002-1943-017X
David L KaplanDepartment of Biomedical Engineering, Tufts University. Medford, MA 02155, USA.ORCID 0000-0002-9245-7774
Darren P WallaceDepartment of Medicine and the Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Aldebaran M HoferDepartment of Surgery, Harvard Medical School, Brigham and Women's Hospital, MA 02132, USA.
Barbara E EhrlichDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA. barbara.ehrlich@yale.edu ikuo@luc.edu.ORCID 0000-0001-9657-9704
Yale University · USBrigham and Women's Hospital · USTufts University · USUniversity of Kansas Medical Center · US
Funding
Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MTranslational CoreP01DK057751 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2001 to 2020
$25.6MRenal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S. · 2008 to 2022
$16.8MEngineering erythropoietin-producing cellsR24DK106743 · NIDDK · ROGOSIN INSTITUTE · PI CARROLL, THOMAS JOSEPH, CLEAVER, ONDINE B · 2015 to 2019
$7.0MINSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32GM007324 · NIGMS · YALE UNIVERSITY · PI BENNETT, ANTON M · 1987 to 2022
$6.2MCenter for Polycystic Kidney Disease Research at YaleP30DK090744 · NIDDK · YALE UNIVERSITY · PI CAPLAN, MICHAEL J. · 2010 to 2014
$5.6MPilot and Feasibility CoreP30DK106912 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CALVET, JAMES P · 2015 to 2019
$5.5MNon-hypertensive cardiac disorders in polycystic kidney diseaseR00DK101585 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI KUO, IVANA Y · 2017 to 2019
$747kA super-resolution microscope for research and educationS10OD020142 · OD · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2015 to 2015
$600kNon-hypertensive cardiac disorders in polycystic kidney diseaseK99DK101585 · NIDDK · YALE UNIVERSITY · PI KUO, IVANA Y · 2015 to 2016
$182kBLRD VA I01 BX000968NCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR001863NIBIB NIH HHS F31 EB018718NIDDK NIH HHS F31 DK118836NIDDK NIH HHS K99 DK101585NIDDK NIH HHS P01 DK057751NIDDK NIH HHS P30 DK034989NIDDK NIH HHS P30 DK079310NIDDK NIH HHS P30 DK090744NIDDK NIH HHS P30 DK106912NIDDK NIH HHS R00 DK101585NIDDK NIH HHS R24 DK106743NIGMS NIH HHS T32 GM007324NIH HHS S10 OD020142
Abstract
Mitochondria and the endoplasmic reticulum (ER) have an intimate functional relationship due to tethering proteins that bring their membranes in close (~30 nm) apposition. One function of this interorganellar junction is to increase the efficiency of Ca
Indexed as
Energy MetabolismSignal TransductionAnimalsCalciumCells, CulturedEndoplasmic ReticulumGene Expression RegulationGTP PhosphohydrolasesHumansLLC-PK1 CellsMice, KnockoutMitochondriaPolycystic Kidney, Autosomal DominantRNA InterferenceSwineTRPP Cation ChannelsCalciumGTP PhosphohydrolasesMfn2 protein, mouseTRPP Cation Channels
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.