Evidence map›Paper›PMID 31064880›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Peroxisomal β-oxidation regulates histone acetylation and DNA methylation in

Lishuan Wang, Chunlei Wang, Xinye Liu, Jinkui Cheng, Shaofang Li, Jian-Kang Zhu, Zhizhong Gong

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 65 citations in OpenAlex.

  1. Linking cellular metabolism to chromatin modifications in plants.Journal of integrative plant biology · 2026
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  18. Functional Characterization ofFrontiers in plant science · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Lishuan WangState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, 100193 Beijing, China.
Chunlei WangCollege of Horticulture, Gansu Agricultural University, 730070 Lanzhou, China.
Xinye LiuMinistry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Sciences, Hebei Normal University, 050024 Shijiazhuang, China.
Jinkui ChengState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, 100193 Beijing, China.
Shaofang LiState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, 100193 Beijing, China.
Jian-Kang ZhuShanghai Center for Plant Stress Biology, National Key Laboratory of Plant Molecular Genetics, Center of Excellence in Molecular Plant Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 200032 Shanghai, China; jkzhu@sibs.ac.cn gongzz@cau.edu.cn.ORCID 0000-0001-5134-731X
Zhizhong GongState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, 100193 Beijing, China; jkzhu@sibs.ac.cn gongzz@cau.edu.cn.
China Agricultural University · CNChinese Academy of Sciences · CNGansu Agricultural University · CNHebei Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic markers, such as histone acetylation and DNA methylation, determine chromatin organization. In eukaryotic cells, metabolites from organelles or the cytosol affect epigenetic modifications. However, the relationships between metabolites and epigenetic modifications are not well understood in plants. We found that peroxisomal acyl-CoA oxidase 4 (ACX4), an enzyme in the fatty acid β-oxidation pathway, is required for suppressing the silencing of some endogenous loci, as well as

Indexed as

DNA MethylationEpigenesis, GeneticAcetylationAcyl-CoA OxidaseArabidopsisArabidopsis ProteinsATP Citrate (pro-S)-LyaseFatty AcidsGene Expression Regulation, PlantHistonesOxidation-ReductionPeroxisomesPlants, Genetically ModifiedPotassium Channels, Voltage-GatedACX4 protein, ArabidopsisAcyl-CoA OxidaseArabidopsis ProteinsATP Citrate (pro-S)-LyaseFatty AcidsHistonesKAT2 protein, ArabidopsisMFP2 protein, ArabidopsisPotassium Channels, Voltage-Gatedacetyl-CoADNA methylationgene silencinghistone acetylationβ-oxidation

Identifiers

PMID31064880
PMCPMC6534973
OpenAlexW2944427928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.