Evidence map›Paper›PMID 31064843›Full record

ArticleThe Journal of biological chemistry2019

Defining new mechanistic roles for αII spectrin in cardiac function.

Ellen R Lubbers, Nathaniel P Murphy, Hassan Musa, Claire Yu-Mei Huang, Rohan Gupta, Morgan V Price, Mei Han, Georges Daoud, Daniel Gratz, Mona El Refaey and 14 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. HumanizedCells · 2022
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 2 institutions in 2 countries.

Ellen R LubbersFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.ORCID 0000-0002-0357-5681
Nathaniel P MurphyFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Hassan MusaFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Claire Yu-Mei Huangthe Department of Neuroscience and Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, Texas 77030, and.
Rohan GuptaFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Morgan V PriceFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Mei HanFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Georges DaoudFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.ORCID 0000-0003-3354-957X
Daniel GratzFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Mona El RefaeyFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Xianyao XuFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Nicole K HoeflingerFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Emma L FrielFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Peter LancioneFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Michael J WallaceFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Omer CavusFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Samantha L SimmonsFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Jordan L WilliamsFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Michel SkafFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Sara N KoenigFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Paul M L JanssenFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Matthew N Rasbandthe Department of Neuroscience and Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, Texas 77030, and.
Thomas J HundFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia.
Peter J MohlerFrom the Dorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia, Peter.Mohler@osumc.edu.
Heart Rhythm Society · USBaylor College of Medicine · US

Funding

Defining novel mechanisms for human arrhythmiaR35HL135754 · NHLBI · OHIO STATE UNIVERSITY · PI MOHLER, PETER J. · 2017 to 2023
$6.0M
Defining novel mechanisms for regulation of atrial INa and arrhythmiasR01HL134824 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY, MOHLER, PETER J. · 2017 to 2020
$3.0M
EHD proteins in cardiac membrane protein targeting and remodelingR01HL114383 · NHLBI · OHIO STATE UNIVERSITY · PI BOYDEN, PENELOPE ALTMAN, MOHLER, PETER J. · 2013 to 2016
$2.1M
Defining the Impact of E-Cigarettes on Cardiac PathophysiologyR01HL139348 · NHLBI · OHIO STATE UNIVERSITY · PI WOLD, LOREN EUGENE · 2017 to 2020
$1.9M
CaMKII-dependent regulation of cardiac excitabilityR01HL114893 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2012 to 2016
$1.9M
Spectrin-based regulation of cardiac remodeling and heart failureR01HL135096 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2017 to 2020
$1.6M
Defining new pathways for cardiac automaticityK99HL146969 · NHLBI · OHIO STATE UNIVERSITY · PI EL REFAEY, MONA · 2019 to 2020
$194k
Defining the Role of Alpha II Spectrin in Cardiac Function and DiseaseF30HL137331 · NHLBI · OHIO STATE UNIVERSITY · PI LUBBERS, ELLEN · 2017 to 2020
$176k
Defining Novel Mechanisms underlying Human Arrhythmogenic CardiomyopathyF30HL137325 · NHLBI · OHIO STATE UNIVERSITY · PI MURPHY, NATHANIEL PATRICK · 2017 to 2020
$163k
NHLBI NIH HHS F30 HL137325NHLBI NIH HHS F30 HL137331NHLBI NIH HHS K99 HL146969NHLBI NIH HHS R01 HL114383NHLBI NIH HHS R01 HL114893NHLBI NIH HHS R01 HL134824NHLBI NIH HHS R01 HL135096NHLBI NIH HHS R01 HL139348NHLBI NIH HHS R35 HL135754
6 · The paper itself

Abstract

Spectrins are cytoskeletal proteins essential for membrane biogenesis and regulation and serve critical roles in protein targeting and cellular signaling. αII spectrin (

Indexed as

Disease Models, AnimalAnimalsArrhythmias, CardiacCells, CulturedFemaleHeart FailureHumansIschemiaMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacPhenotypeSpectrinSpectrinadaptor proteinankryincardiovascular diseasecytoskeletonheartheart failureion channelspectrin

Identifiers

PMID31064843
PMCPMC6579463
OpenAlexW2944683188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.