Evidence map›Paper›PMID 31064831›Full record

ArticlemBio2019

Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway.

John P Haran, Shakti K Bhattarai, Sage E Foley, Protiva Dutta, Doyle V Ward, Vanni Bucci, Beth A McCormick

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 241 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
241citing papers in PubMed, 11 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

241 citing papers in PubMed, 11 syntheses or guidelines pooled it, 390 citations in OpenAlex.

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181 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

John P Haran *Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA john.haran@umassmed.edu.ORCID 0000-0001-7311-1121
Shakti K Bhattarai *Department of Bioengineering, Program in Engineering and Applied Sciences, University of Massachusetts Dartmouth, North Dartmouth, Massachusetts, USA.
Sage E FoleyDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Protiva DuttaDepartment of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Doyle V WardDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Vanni BucciDepartment of Bioengineering, Program in Engineering and Applied Sciences, University of Massachusetts Dartmouth, North Dartmouth, Massachusetts, USA.
Beth A McCormickDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
University of Massachusetts Chan Medical School · USUniversity of Massachusetts Dartmouth · US

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JERROLD R. TURNER · 1986 to 2026
$32.4M
INTESTINAL INFLAMMATION ORCHESTRATED BY PATHOGENSR01DK056754 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCCORMICK, BETH A · 2000 to 2017
$6.5M
TRAINING IN IMMUNOLOGY (COMPETITIVE RENEWAL OF AI07439)T32AI007349 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 1989 to 2024
$4.5M
The elderly gut microbiome during transition to long-term care and the risk of Clostridium difficile carriageK23AG057790 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HARAN, JOHN PATRICK · 2018 to 2021
$757k
Mathematical modeling from metagenomics - minimizing risk of enteric infectionsR15AI112985 · NIAID · UNIVERSITY OF MASSACHUSETTS DARTMOUTH · PI BUCCI, VANNI · 2015 to 2015
$465k
Study of the Intestinal Microbiome, Antimicrobial Use, and Clostridium difficile Infections in Long-term Care Facility ResidentsR03AG056356 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HARAN, JOHN PATRICK · 2017 to 2018
$251k
NIAID NIH HHS R15 AI112985NIAID NIH HHS T32 AI007349NIA NIH HHS K23 AG057790NIA NIH HHS R03 AG056356NIDDK NIH HHS R01 DK056754
6 · The paper itself

Abstract

The microbiota-gut-brain axis is a bidirectional communication system that is poorly understood. Alzheimer's disease (AD), the most common cause of dementia, has long been associated with bacterial infections and inflammation-causing immunosenescence. Recent studies examining the intestinal microbiota of AD patients revealed that their microbiome differs from that of subjects without dementia. In this work, we prospectively enrolled 108 nursing home elders and followed each for up to 5 months, collecting longitudinal stool samples from which we performed metagenomic sequencing and

Indexed as

DysbiosisGastrointestinal MicrobiomeAgedAged, 80 and overAlzheimer DiseaseATP Binding Cassette Transporter, Subfamily BBacteriaDementiaEpithelial CellsFecesFemaleHomeostasisHumansInflammationIntestinesMachine LearningATP Binding Cassette Transporter, Subfamily BRNA, Ribosomal, 16SAlzheimer’s Diseasedementiaelderlygut-brain axisintestinal homeostasisintestinal microbiome

Identifiers

PMID31064831
PMCPMC6509190
OpenAlexW2944552216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.