Evidence map›Paper›PMID 31064808›Full record

ArticleBMJ open2019

B Part of It School Leaver protocol: an observational repeat cross-sectional study to assess the impact of a meningococcal serogroup B (4CMenB) vaccine programme on carriage of

Helen S Marshall, Mark McMillan, Ann Koehler, Andrew Lawrence, Jenny MacLennan, Martin Maiden, Mary Ramsay, Shamez N Ladhani, Caroline Trotter, Ray Borrow and 6 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03419533 (An Observational Cross-sectional Study to Assess Oropharyngeal Carriage of N. Meningitidis in South Australian School Leavers), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03419533 completednot on this map

An Observational Cross-sectional Study to Assess Oropharyngeal Carriage of N. Meningitidis in South Australian School Leavers

TypeobservationalSponsorUniversity of AdelaideRan2018 to 2020Enrolled6,802ConditionsNeisseria Meningitidis
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 4 countries.

Helen S MarshallVaccinology and Immunology Research Trials Unit, Women's and Children's Health Network, North Adelaide, South Australia, Australia.ORCID 0000-0003-2521-5166
Mark McMillanVaccinology and Immunology Research Trials Unit, Women's and Children's Health Network, North Adelaide, South Australia, Australia.ORCID 0000-0002-6490-7707
Ann KoehlerCommunicable Disease Control Branch, SA Health, Adelaide, South Australia, Australia.
Andrew LawrenceMicrobiology Department, SA Pathology, Adelaide, South Australia, Australia.
Jenny MacLennanDepartment of Zoology, University of Oxford, Oxford, UK.
Martin MaidenDepartment of Zoology, University of Oxford, Oxford, UK.
Mary RamsayImmunisation Department, Public Health England, London, UK.
Shamez N LadhaniImmunisation Department, Public Health England, London, UK.
Caroline TrotterImmunisation Department, Public Health England, London, UK.
Ray BorrowMeningococcal Reference Unit, Public Health England, Manchester, UK.
Adam FinnSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Thomas SullivanSchool of Public Health, The University of Adelaide, Adelaide, South Australia, Australia.
Peter RichmondWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Institute for Child Health Research, University of Western Australia, Perth, Western Australia, Australia.
Charlene KahlerMarshall Centre for Infectious Disease Research and Training, School of Biomedical Science, University of Western Australia, Perth, Western Australia, Australia.
Jane WhelanGlaxoSmithKline Vaccines, Amsterdam, Netherlands.
Kumaran VadiveluGlaxoSmith Kline Vaccines, Rockville, Maryland, USA.
Public Health England · GBUniversity of Oxford · GBWomen's and Children's Health Network · AUGlaxoSmithKline (Netherlands) · NLGlaxoSmithKline (United States) · USSA Health · AUSouth Australia Pathology · AUThe Kids Research Institute Australia · AUThe University of Adelaide · AUThe University of Western Australia · AUUniversity of Bristol · GBUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInvasive meningococcal disease is uncommon but associated with a high-case fatality rate. Carriage prevalence of the causative bacteria, METHODS AND ANALYSIS: This repeat cross-sectional study will assess carriage prevalence in 2018 and 2019. All school leavers who attended year 12 in any school in SA in 2018 or 2019 will be invited to participate in this study. An oropharyngeal swab will be taken from each participating student and a risk factor questionnaire completed by the student following informed consent. Students will attend clinics at SA universities, technical colleges, and metropolitan, rural and remote government council clinics. Confirmed vaccination history will allow a comparison in carriage prevalence between vaccinated and unvaccinated school leavers. A sample size of 4096 students per year will provide 80% power to detect a 20% difference in carriage prevalence of disease-causing meningococci (defined as genogroup A, B, C, W, X or Y) between years. ETHICS AND DISSEMINATION: The study was approved by the Women's and Children's Health Network Human Research Ethics Committee. Results will be published in international peer review journals and presented at national and international conferences. TRIAL REGISTRATION NUMBER: NCT03419533; Pre-results.

Indexed as

Meningococcal InfectionsMeningococcal VaccinesNeisseria meningitidis, Serogroup BAdolescentAdultCross-Sectional StudiesFemaleHumansMaleObservational Studies as TopicPrevalenceProgram EvaluationSouth AustraliaYoung AdultMeningococcal Vaccinesadolescentbacterial loadmeningococcal vaccinesNeisseria meningitidisrisk factorssmoking

Identifiers

PMID31064808
PMCPMC6528050
OpenAlexW2944033209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.