Evidence map›Paper›PMID 31064775›Full record

ArticleDisease models & mechanisms2019

Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice.

Susan M Motch Perrine, Meng Wu, Nicholas B Stephens, Divya Kriti, Harm van Bakel, Ethylin Wang Jabs, Joan T Richtsmeier

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03025763 (Craniosynostosis Network), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03025763 active not recruitingnot on this map

Craniosynostosis Network

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2015 to 2028Enrolled2,145ConditionsCraniosynostosisArmsCraniosynostosis Network Environmental Survey, 2D/3D Photography, Buccal Swab Cell Sampling, Blood sampling, Skin Biopsy
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Dosage-dependent effects of FGFR2Anatomical record (Hoboken, N.J. : 2007) · 2025
    Article
  5. Article
  6. Article
  7. [Role of Fibroblast Growth Factor 7 in Craniomaxillofacial Development].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. EctomesenchymalFrontiers in genetics · 2023
    Article
  12. Article
  13. Review
  14. Embryonic and early postnatal cranial bone volume and tissue mineral density values for C57BL/6J laboratory mice.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Susan M Motch PerrineDepartment of Anthropology, Pennsylvania State University, University Park, PA 16802, USA.
Meng WuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA meng.wu@mssm.edu.ORCID 0000-0001-5512-9651
Nicholas B StephensDepartment of Anthropology, Pennsylvania State University, University Park, PA 16802, USA.
Divya KritiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-9357-5588
Harm van BakelDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-1376-6916
Ethylin Wang JabsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-8983-5466
Joan T RichtsmeierDepartment of Anthropology, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-0239-5822
Icahn School of Medicine at Mount Sinai · USPennsylvania State University · US

Funding

Project III: Systems Biology of Bone in Coronal Nonsyndromic CraniosynostosisP01HD078233 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DREW, PATRICK JAMES, JABS, ETHYLIN WANG · 2014 to 2019
$7.0M
Midface and Upper Airway in CraniosynostosisR01DE022988 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI JABS, ETHYLIN WANG, RICHTSMEIER, JOAN THERESE · 2012 to 2016
$3.1M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
NICHD NIH HHS P01 HD078233NIDCR NIH HHS R01 DE022988NIH HHS S10 OD018522
6 · The paper itself

Abstract

One diagnostic feature of craniosynostosis syndromes is mandibular dysgenesis. Using three mouse models of Apert, Crouzon and Pfeiffer craniosynostosis syndromes, we investigated how embryonic development of the mandible is affected by fibroblast growth factor receptor 2 (

Indexed as

OsteogenesisAnimalsCell ProliferationChondrocytesCraniosynostosesDiphosphatesDisease Models, AnimalEmbryo, MammalianMandibleMiceModels, BiologicalOsteoblastsReceptor, Fibroblast Growth Factor, Type 2DiphosphatesReceptor, Fibroblast Growth Factor, Type 2Apert syndromeCartilageCrouzon syndromeFGFR2OsteoclastPfeiffer syndromeTranscriptome

Identifiers

PMID31064775
PMCPMC6550049
OpenAlexW2944146820

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.