Evidence map›Paper›PMID 31064769›Full record

ArticleDisease models & mechanisms2019

Disruption of

Evisa Gjini, Chang-Bin Jing, Ashley T Nguyen, Deepak Reyon, Emma Gans, Michiel Kesarsing, Joshua Peterson, Olga Pozdnyakova, Scott J Rodig, Marc R Mansour and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Modeling hematopoietic disorders in zebrafish.Disease models & mechanisms · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Evisa GjiniDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts 02215, USA thomas_look@dfci.harvard.edu evisa_gjini@dfci.harvard.edu.ORCID 0000-0002-3315-1687
Chang-Bin JingDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts 02215, USA.
Ashley T NguyenDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts 02215, USA.
Deepak ReyonMolecular Pathology Unit, Center for Computational and Integrative Biology, and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
Emma GansDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts 02215, USA.
Michiel KesarsingDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts 02215, USA.
Joshua PetersonDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts 02215, USA.
Olga PozdnyakovaDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Scott J RodigDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Marc R MansourDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts 02215, USA.
Keith JoungMolecular Pathology Unit, Center for Computational and Integrative Biology, and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
A Thomas LookDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts 02215, USA thomas_look@dfci.harvard.edu evisa_gjini@dfci.harvard.edu.ORCID 0000-0001-7851-8617
Harvard University · USBrigham and Women's Hospital · US

Funding

Genetic Basis of Myeloid Neoplasia--Mutagenesis ScreensR01CA093152 · NCI · DANA-FARBER CANCER INSTITUTE · PI LOOK, A THOMAS · 2001 to 2005
$2.1M
NCI NIH HHS R01 CA093152
6 · The paper itself

Abstract

Somatic loss-of-function mutations of the additional sex combs-like transcriptional regulator 1 (

Indexed as

AnimalsApoptosisBase SequenceBone Marrow NeoplasmsCell SurvivalEmbryo, NonmammalianGene EditingHematopoietic Stem CellsLeukemia, Myeloid, AcuteMutationOrganogenesisRepressor ProteinsUp-RegulationZebrafishZebrafish Proteinsasxl1 protein, zebrafishRepressor ProteinsZebrafish ProteinsApoptosisGenome editingHematopoietic stem cellsMyeloproliferative neoplasmsTet2

Identifiers

PMID31064769
PMCPMC6550042
OpenAlexW2944628336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.